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Neurons detect cognitive boundaries to structure episodic memories in humans

While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe during the formati...

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Autores principales: Zheng, Jie, Schjetnan, Andrea G. P., Yebra, Mar, Gomes, Bernard A., Mosher, Clayton P., Kalia, Suneil K., Valiante, Taufik A., Mamelak, Adam N., Kreiman, Gabriel, Rutishauser, Ueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966433/
https://www.ncbi.nlm.nih.gov/pubmed/35260859
http://dx.doi.org/10.1038/s41593-022-01020-w
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author Zheng, Jie
Schjetnan, Andrea G. P.
Yebra, Mar
Gomes, Bernard A.
Mosher, Clayton P.
Kalia, Suneil K.
Valiante, Taufik A.
Mamelak, Adam N.
Kreiman, Gabriel
Rutishauser, Ueli
author_facet Zheng, Jie
Schjetnan, Andrea G. P.
Yebra, Mar
Gomes, Bernard A.
Mosher, Clayton P.
Kalia, Suneil K.
Valiante, Taufik A.
Mamelak, Adam N.
Kreiman, Gabriel
Rutishauser, Ueli
author_sort Zheng, Jie
collection PubMed
description While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe during the formation and retrieval of memories with complex narratives. Here we show that neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval.
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spelling pubmed-89664332022-09-07 Neurons detect cognitive boundaries to structure episodic memories in humans Zheng, Jie Schjetnan, Andrea G. P. Yebra, Mar Gomes, Bernard A. Mosher, Clayton P. Kalia, Suneil K. Valiante, Taufik A. Mamelak, Adam N. Kreiman, Gabriel Rutishauser, Ueli Nat Neurosci Article While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe during the formation and retrieval of memories with complex narratives. Here we show that neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval. 2022-03 2022-03-07 /pmc/articles/PMC8966433/ /pubmed/35260859 http://dx.doi.org/10.1038/s41593-022-01020-w Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Zheng, Jie
Schjetnan, Andrea G. P.
Yebra, Mar
Gomes, Bernard A.
Mosher, Clayton P.
Kalia, Suneil K.
Valiante, Taufik A.
Mamelak, Adam N.
Kreiman, Gabriel
Rutishauser, Ueli
Neurons detect cognitive boundaries to structure episodic memories in humans
title Neurons detect cognitive boundaries to structure episodic memories in humans
title_full Neurons detect cognitive boundaries to structure episodic memories in humans
title_fullStr Neurons detect cognitive boundaries to structure episodic memories in humans
title_full_unstemmed Neurons detect cognitive boundaries to structure episodic memories in humans
title_short Neurons detect cognitive boundaries to structure episodic memories in humans
title_sort neurons detect cognitive boundaries to structure episodic memories in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966433/
https://www.ncbi.nlm.nih.gov/pubmed/35260859
http://dx.doi.org/10.1038/s41593-022-01020-w
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