Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood

Leukotrienes are pro-inflammatory lipid mediators generated by 5-lipoxygenase aided by the 5-lipoxygenase-activating protein (FLAP). BRP-201, a novel benzimidazole-based FLAP antagonist, inhibits leukotriene biosynthesis in isolated leukocytes. However, like other FLAP antagonists, BRP-201 fails to...

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Detalles Bibliográficos
Autores principales: Kretzer, Christian, Shkodra, Blerina, Klemm, Paul, Jordan, Paul M., Schröder, Daniel, Cinar, Gizem, Vollrath, Antje, Schubert, Stephanie, Nischang, Ivo, Hoeppener, Stephanie, Stumpf, Steffi, Banoglu, Erden, Gladigau, Frederike, Bilancia, Rossella, Rossi, Antonietta, Eggeling, Christian, Neugebauer, Ute, Schubert, Ulrich S., Werz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966466/
https://www.ncbi.nlm.nih.gov/pubmed/34971430
http://dx.doi.org/10.1007/s00018-021-04039-7

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