From Helicobacter pylori infection to gastric cancer: Current evidence on the immune response

Gastric cancer (GC) is the result of a multifactorial process whose main components are infection by Helicobacter pylori (H. pylori), bacterial virulence factors, host immune response and environmental factors. The development of the neoplastic microenvironment also depends on genetic and epigenetic...

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Detalles Bibliográficos
Autores principales: Lima de Souza Gonçalves, Vinícius, Cordeiro Santos, Maria Luísa, Silva Luz, Marcel, Santos Marques, Hanna, de Brito, Breno Bittencourt, França da Silva, Filipe Antônio, Souza, Cláudio Lima, Oliveira, Márcio Vasconcelos, de Melo, Fabrício Freire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966509/
https://www.ncbi.nlm.nih.gov/pubmed/35433296
http://dx.doi.org/10.5306/wjco.v13.i3.186
Descripción
Sumario:Gastric cancer (GC) is the result of a multifactorial process whose main components are infection by Helicobacter pylori (H. pylori), bacterial virulence factors, host immune response and environmental factors. The development of the neoplastic microenvironment also depends on genetic and epigenetic changes in oncogenes and tumor suppressor genes, which results in deregulation of cell signaling pathways and apoptosis process. This review summarizes the main aspects of the pathogenesis of GC and the immune response involved in chronic inflammation generated by H. pylori.

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