Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation

Misuse of pyrrolizidine alkaloid (PA)-containing plants or consumption of PA-contaminated foodstuffs causes numerous poisoning cases in humans yearly, while effective therapeutic strategies are still limited. PA-induced liver injury was initiated by cytochrome P450 (CYP)-mediated metabolic activatio...

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Detalles Bibliográficos
Autores principales: Wang, Zhangting, Ma, Jiang, Yao, Sheng, He, Yisheng, Miu, Kai-Kei, Xia, Qingsu, Fu, Peter P., Ye, Yang, Lin, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966664/
https://www.ncbi.nlm.nih.gov/pubmed/35370657
http://dx.doi.org/10.3389/fphar.2022.850859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966664/
https://www.ncbi.nlm.nih.gov/pubmed/35370657
http://dx.doi.org/10.3389/fphar.2022.850859

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