Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients

Background: The aim was to explore a novel risk score to predict mortality in hospitalized patients with COVID-19 pneumonia. Methods: This was a retrospective, multicenter study. Results: A total of 1013 patients with COVID-19 were included. The mean age was 60.5 ± 14.4 years, and 581 (57.4%) patien...

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Autores principales: Surme, Serkan, Tuncer, Gulsah, Bayramlar, Osman F, Copur, Betul, Zerdali, Esra, Nakir, Inci Y, Yazla, Meltem, Buyukyazgan, Ahmet, Cinar, Ayse RK, Kurekci, Yesim, Alkan, Mustafa, Ozdemir, Yusuf E, Sengoz, Gonul, Pehlivanoglu, Filiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966692/
https://www.ncbi.nlm.nih.gov/pubmed/35350866
http://dx.doi.org/10.2217/bmm-2021-1085
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author Surme, Serkan
Tuncer, Gulsah
Bayramlar, Osman F
Copur, Betul
Zerdali, Esra
Nakir, Inci Y
Yazla, Meltem
Buyukyazgan, Ahmet
Cinar, Ayse RK
Kurekci, Yesim
Alkan, Mustafa
Ozdemir, Yusuf E
Sengoz, Gonul
Pehlivanoglu, Filiz
author_facet Surme, Serkan
Tuncer, Gulsah
Bayramlar, Osman F
Copur, Betul
Zerdali, Esra
Nakir, Inci Y
Yazla, Meltem
Buyukyazgan, Ahmet
Cinar, Ayse RK
Kurekci, Yesim
Alkan, Mustafa
Ozdemir, Yusuf E
Sengoz, Gonul
Pehlivanoglu, Filiz
author_sort Surme, Serkan
collection PubMed
description Background: The aim was to explore a novel risk score to predict mortality in hospitalized patients with COVID-19 pneumonia. Methods: This was a retrospective, multicenter study. Results: A total of 1013 patients with COVID-19 were included. The mean age was 60.5 ± 14.4 years, and 581 (57.4%) patients were male. In-hospital death occurred in 124 (12.2%) patients. Multivariate analysis revealed peripheral capillary oxygen saturation (SpO2), albumin, D-dimer and age as independent predictors. The mortality score model was given the acronym SAD-60, representing SpO2, Albumin, D-dimer, age ≥60 years. The SAD-60 score (0.776) had the highest area under the curve compared with CURB-65 (0.753), NEWS2 (0.686) and qSOFA (0.628) scores. Conclusion: The SAD-60 score has a promising predictive capacity for mortality in hospitalized patients with COVID-19.
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spelling pubmed-89666922022-03-31 Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients Surme, Serkan Tuncer, Gulsah Bayramlar, Osman F Copur, Betul Zerdali, Esra Nakir, Inci Y Yazla, Meltem Buyukyazgan, Ahmet Cinar, Ayse RK Kurekci, Yesim Alkan, Mustafa Ozdemir, Yusuf E Sengoz, Gonul Pehlivanoglu, Filiz Biomark Med Research Article Background: The aim was to explore a novel risk score to predict mortality in hospitalized patients with COVID-19 pneumonia. Methods: This was a retrospective, multicenter study. Results: A total of 1013 patients with COVID-19 were included. The mean age was 60.5 ± 14.4 years, and 581 (57.4%) patients were male. In-hospital death occurred in 124 (12.2%) patients. Multivariate analysis revealed peripheral capillary oxygen saturation (SpO2), albumin, D-dimer and age as independent predictors. The mortality score model was given the acronym SAD-60, representing SpO2, Albumin, D-dimer, age ≥60 years. The SAD-60 score (0.776) had the highest area under the curve compared with CURB-65 (0.753), NEWS2 (0.686) and qSOFA (0.628) scores. Conclusion: The SAD-60 score has a promising predictive capacity for mortality in hospitalized patients with COVID-19. Future Medicine Ltd 2022-03-30 2022-01 /pmc/articles/PMC8966692/ /pubmed/35350866 http://dx.doi.org/10.2217/bmm-2021-1085 Text en © 2022 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Surme, Serkan
Tuncer, Gulsah
Bayramlar, Osman F
Copur, Betul
Zerdali, Esra
Nakir, Inci Y
Yazla, Meltem
Buyukyazgan, Ahmet
Cinar, Ayse RK
Kurekci, Yesim
Alkan, Mustafa
Ozdemir, Yusuf E
Sengoz, Gonul
Pehlivanoglu, Filiz
Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients
title Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients
title_full Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients
title_fullStr Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients
title_full_unstemmed Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients
title_short Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients
title_sort novel biomarker-based score (sad-60) for predicting mortality in patients with covid-19 pneumonia: a multicenter retrospective cohort of 1013 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966692/
https://www.ncbi.nlm.nih.gov/pubmed/35350866
http://dx.doi.org/10.2217/bmm-2021-1085
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