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Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans
Retrieval practice improves retention of information in long-term memory more than restudy, but the underlying neural mechanisms of this “retrieval practice effect” (RPE) remain poorly understood. Therefore, we investigated the behavioral and neural differences between previously retrieved versus re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966694/ https://www.ncbi.nlm.nih.gov/pubmed/35372838 http://dx.doi.org/10.1093/texcom/tgac009 |
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author | Guran, Catherine-Noémie Alexandrina Deuker, Lorena Göttlich, Martin Axmacher, Nikolai Bunzeck, Nico |
author_facet | Guran, Catherine-Noémie Alexandrina Deuker, Lorena Göttlich, Martin Axmacher, Nikolai Bunzeck, Nico |
author_sort | Guran, Catherine-Noémie Alexandrina |
collection | PubMed |
description | Retrieval practice improves retention of information in long-term memory more than restudy, but the underlying neural mechanisms of this “retrieval practice effect” (RPE) remain poorly understood. Therefore, we investigated the behavioral and neural differences between previously retrieved versus restudied items at final retrieval. Thirty younger (20–30 years old) and twenty-five older (50+ years old) adults learned familiar and new picture stimuli either through retrieval or restudy. At final recognition, hemodynamic activity was measured using functional magnetic resonance imaging (fMRI). Behaviorally, younger and older adults showed similar benefits of retrieval practice, with higher recollection, but unchanged familiarity rates. In a univariate analysis of the fMRI data, activation in medial prefrontal cortex and left temporal regions correlated with an individual’s amount of behavioral benefit from retrieval practice, irrespective of age. Compatible with this observation, in a multivariate representational similarity analysis (RSA), retrieval practice led to an increase in pattern similarity for retested items in a priori defined regions of interest, including the medial temporal lobe, as well as prefrontal and parietal cortex. Our findings demonstrate that retrieval practice leads to enhanced long-term memories in younger and older adults alike, and this effect may be driven by fast consolidation processes. |
format | Online Article Text |
id | pubmed-8966694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89666942022-03-31 Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans Guran, Catherine-Noémie Alexandrina Deuker, Lorena Göttlich, Martin Axmacher, Nikolai Bunzeck, Nico Cereb Cortex Commun Original Article Retrieval practice improves retention of information in long-term memory more than restudy, but the underlying neural mechanisms of this “retrieval practice effect” (RPE) remain poorly understood. Therefore, we investigated the behavioral and neural differences between previously retrieved versus restudied items at final retrieval. Thirty younger (20–30 years old) and twenty-five older (50+ years old) adults learned familiar and new picture stimuli either through retrieval or restudy. At final recognition, hemodynamic activity was measured using functional magnetic resonance imaging (fMRI). Behaviorally, younger and older adults showed similar benefits of retrieval practice, with higher recollection, but unchanged familiarity rates. In a univariate analysis of the fMRI data, activation in medial prefrontal cortex and left temporal regions correlated with an individual’s amount of behavioral benefit from retrieval practice, irrespective of age. Compatible with this observation, in a multivariate representational similarity analysis (RSA), retrieval practice led to an increase in pattern similarity for retested items in a priori defined regions of interest, including the medial temporal lobe, as well as prefrontal and parietal cortex. Our findings demonstrate that retrieval practice leads to enhanced long-term memories in younger and older adults alike, and this effect may be driven by fast consolidation processes. Oxford University Press 2022-02-17 /pmc/articles/PMC8966694/ /pubmed/35372838 http://dx.doi.org/10.1093/texcom/tgac009 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Guran, Catherine-Noémie Alexandrina Deuker, Lorena Göttlich, Martin Axmacher, Nikolai Bunzeck, Nico Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
title | Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
title_full | Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
title_fullStr | Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
title_full_unstemmed | Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
title_short | Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
title_sort | benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966694/ https://www.ncbi.nlm.nih.gov/pubmed/35372838 http://dx.doi.org/10.1093/texcom/tgac009 |
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