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Diazido macrocyclic sulfates as a platform for the synthesis of sequence-defined polymers for antibody drug conjugates
To improve the efficacy of antibody drug conjugates (ADCs), there has been significant focus on increasing the drug-to-antibody ratio (DAR) in order to deliver more payload. However, due to the hydrophobicity of many cytotoxics, highly-loaded conjugates often have lower physicochemical stability and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966716/ https://www.ncbi.nlm.nih.gov/pubmed/35432892 http://dx.doi.org/10.1039/d1sc06242e |