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Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner
INTRODUCTION: Focal osteoporosis defect has shown a high association with the bone fragility and osteoporotic fracture prevalence. However, no routine computed tomography (CT)‐based vertebral focal osteoporosis defect measurement and its association with vertebral compression fracture (VCF) were dis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966878/ https://www.ncbi.nlm.nih.gov/pubmed/35386753 http://dx.doi.org/10.1002/jsp2.1195 |
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author | Li, Chentian Ma, Chi Zhuo, Xianglong Li, Li Li, Bing Li, Songjian Lu, William W. |
author_facet | Li, Chentian Ma, Chi Zhuo, Xianglong Li, Li Li, Bing Li, Songjian Lu, William W. |
author_sort | Li, Chentian |
collection | PubMed |
description | INTRODUCTION: Focal osteoporosis defect has shown a high association with the bone fragility and osteoporotic fracture prevalence. However, no routine computed tomography (CT)‐based vertebral focal osteoporosis defect measurement and its association with vertebral compression fracture (VCF) were discussed yet. This study aimed to develop a routine CT‐based measurement method for focal osteoporosis defect quantification, and to assess its association with the VCF prevalence. MATERIALS AND METHODS: A total of 205 cases who underwent routine CT scanning, were retrospectively reviewed and enrolled into either the VCF or the control group. The focal bone mineral content loss (focal BMC loss), measured as the cumulated demineralization within bone void space, was proposed for focal osteoporosis defect quantification. Its scan‐rescan reproducibility and its correlation with trabecular bone mineral density (BMD) and apparent microarchitecture parameters were evaluated. The association between focal BMC loss and the prevalence of VCF was studied by logistic regression. RESULTS: The measurement of focal BMC loss showed high reproducibility (RMSSD = 0.011 mm, LSC = 0.030 mm, ICC = 0.97), and good correlation with focal bone volume fraction (r = 0.79, P < 0.001), trabecular bone separation (r = 0.76, P < 0.001), but poor correlation with trabecular BMD (r = 0.37, P < 0.001). The focal BMC loss was significantly higher in the fracture group than the control (1.03 ± 0.13 vs. 0.93 ± 0.11 mm; P < 0.001), and was associated with prevalent VCF (1.87, 95% CI = 1.31–2.65, P < 0.001) independent of trabecular BMD level. DISCUSSION: As a surrogate measure of focal osteoporosis defect, focal BMC Loss independently associated with the VCF prevalence. It suggests that focal osteoporosis defect is a common manifestation that positively contributed to compression fracture risk and can be quantified with routine CT using focal BMC Loss. |
format | Online Article Text |
id | pubmed-8966878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89668782022-04-05 Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner Li, Chentian Ma, Chi Zhuo, Xianglong Li, Li Li, Bing Li, Songjian Lu, William W. JOR Spine Special Issue on China Papers (Part 2) INTRODUCTION: Focal osteoporosis defect has shown a high association with the bone fragility and osteoporotic fracture prevalence. However, no routine computed tomography (CT)‐based vertebral focal osteoporosis defect measurement and its association with vertebral compression fracture (VCF) were discussed yet. This study aimed to develop a routine CT‐based measurement method for focal osteoporosis defect quantification, and to assess its association with the VCF prevalence. MATERIALS AND METHODS: A total of 205 cases who underwent routine CT scanning, were retrospectively reviewed and enrolled into either the VCF or the control group. The focal bone mineral content loss (focal BMC loss), measured as the cumulated demineralization within bone void space, was proposed for focal osteoporosis defect quantification. Its scan‐rescan reproducibility and its correlation with trabecular bone mineral density (BMD) and apparent microarchitecture parameters were evaluated. The association between focal BMC loss and the prevalence of VCF was studied by logistic regression. RESULTS: The measurement of focal BMC loss showed high reproducibility (RMSSD = 0.011 mm, LSC = 0.030 mm, ICC = 0.97), and good correlation with focal bone volume fraction (r = 0.79, P < 0.001), trabecular bone separation (r = 0.76, P < 0.001), but poor correlation with trabecular BMD (r = 0.37, P < 0.001). The focal BMC loss was significantly higher in the fracture group than the control (1.03 ± 0.13 vs. 0.93 ± 0.11 mm; P < 0.001), and was associated with prevalent VCF (1.87, 95% CI = 1.31–2.65, P < 0.001) independent of trabecular BMD level. DISCUSSION: As a surrogate measure of focal osteoporosis defect, focal BMC Loss independently associated with the VCF prevalence. It suggests that focal osteoporosis defect is a common manifestation that positively contributed to compression fracture risk and can be quantified with routine CT using focal BMC Loss. John Wiley & Sons, Inc. 2022-02-26 /pmc/articles/PMC8966878/ /pubmed/35386753 http://dx.doi.org/10.1002/jsp2.1195 Text en © 2022 The Authors. JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Special Issue on China Papers (Part 2) Li, Chentian Ma, Chi Zhuo, Xianglong Li, Li Li, Bing Li, Songjian Lu, William W. Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
title | Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
title_full | Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
title_fullStr | Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
title_full_unstemmed | Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
title_short | Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
title_sort | focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner |
topic | Special Issue on China Papers (Part 2) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966878/ https://www.ncbi.nlm.nih.gov/pubmed/35386753 http://dx.doi.org/10.1002/jsp2.1195 |
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