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Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study
Working memory functions are known to be altered after total sleep deprivation (TSD). However, few studies have explored the deficits of working memory updating (WMU) after TSD, or the underlying electrophysiological mechanisms of these alterations. In the current exploratory study, we enrolled 14 y...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966886/ https://www.ncbi.nlm.nih.gov/pubmed/35368284 http://dx.doi.org/10.3389/fnins.2022.736437 |
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author | Song, Tao Yu, Ke Wang, Letong Xu, Lin Xu, Mengmeng Peng, Ziyi Dai, Cimin Wang, Haiteng Yang, Tianyi Shao, Yongcong Wang, Xiaoming Lv, Jing |
author_facet | Song, Tao Yu, Ke Wang, Letong Xu, Lin Xu, Mengmeng Peng, Ziyi Dai, Cimin Wang, Haiteng Yang, Tianyi Shao, Yongcong Wang, Xiaoming Lv, Jing |
author_sort | Song, Tao |
collection | PubMed |
description | Working memory functions are known to be altered after total sleep deprivation (TSD). However, few studies have explored the deficits of working memory updating (WMU) after TSD, or the underlying electrophysiological mechanisms of these alterations. In the current exploratory study, we enrolled 14 young male volunteers who performed two kinds of WMU tasks—spatial and object two-back tasks—with simultaneous electroencephalography recordings under two sleep conditions: a normal sleep baseline condition and after 36 h of TSD. Repeated-measures analysis of variance showed that compared with those at baseline, the rates of correct responses in the WMU tasks decreased significantly after TSD. Analysis of event-related potentials revealed that the average amplitude of P3 components decreased significantly in the frontal and central brain regions and increased significantly in the parietal brain regions. Our findings suggest that TSD damages WMU behavior, impairs cognitive functions in the frontal and central brain regions, and triggers greater activation in the parietal brain regions. This is the first study to report the existence of event-related compensatory neural activity. This event-related compensatory effect may provide a new perspective for understanding the mechanisms underlying the influences triggered by sleep loss. |
format | Online Article Text |
id | pubmed-8966886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89668862022-03-31 Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study Song, Tao Yu, Ke Wang, Letong Xu, Lin Xu, Mengmeng Peng, Ziyi Dai, Cimin Wang, Haiteng Yang, Tianyi Shao, Yongcong Wang, Xiaoming Lv, Jing Front Neurosci Neuroscience Working memory functions are known to be altered after total sleep deprivation (TSD). However, few studies have explored the deficits of working memory updating (WMU) after TSD, or the underlying electrophysiological mechanisms of these alterations. In the current exploratory study, we enrolled 14 young male volunteers who performed two kinds of WMU tasks—spatial and object two-back tasks—with simultaneous electroencephalography recordings under two sleep conditions: a normal sleep baseline condition and after 36 h of TSD. Repeated-measures analysis of variance showed that compared with those at baseline, the rates of correct responses in the WMU tasks decreased significantly after TSD. Analysis of event-related potentials revealed that the average amplitude of P3 components decreased significantly in the frontal and central brain regions and increased significantly in the parietal brain regions. Our findings suggest that TSD damages WMU behavior, impairs cognitive functions in the frontal and central brain regions, and triggers greater activation in the parietal brain regions. This is the first study to report the existence of event-related compensatory neural activity. This event-related compensatory effect may provide a new perspective for understanding the mechanisms underlying the influences triggered by sleep loss. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8966886/ /pubmed/35368284 http://dx.doi.org/10.3389/fnins.2022.736437 Text en Copyright © 2022 Song, Yu, Wang, Xu, Xu, Peng, Dai, Wang, Yang, Shao, Wang and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Song, Tao Yu, Ke Wang, Letong Xu, Lin Xu, Mengmeng Peng, Ziyi Dai, Cimin Wang, Haiteng Yang, Tianyi Shao, Yongcong Wang, Xiaoming Lv, Jing Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study |
title | Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study |
title_full | Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study |
title_fullStr | Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study |
title_full_unstemmed | Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study |
title_short | Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study |
title_sort | total sleep deprivation triggers greater activation in the parietal brain in the visual working memory updating processes: an event-related potentials study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966886/ https://www.ncbi.nlm.nih.gov/pubmed/35368284 http://dx.doi.org/10.3389/fnins.2022.736437 |
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