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Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562

A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety via N-containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines. Seven compounds exhibited the highest activity against both cell lines w...

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Detalles Bibliográficos
Autores principales:	El-Dydamony, Nehad M., Abdelnaby, Rana M., Abdelhady, Rasha, Ali, Omaima, Fahmy, Mohamed I., R. Fakhr Eldeen, Rasha, Helwa, Amira A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967206/ https://www.ncbi.nlm.nih.gov/pubmed/35345960 http://dx.doi.org/10.1080/14756366.2022.2051022

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