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A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc h...

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Autores principales: Wang, Xin, Yin, Xiaochen, Zhang, Boya, Liu, Chenfeng, Lin, Yahua, Huang, Xiaofen, Li, Yufang, Shen, Chenguang, Zheng, Weibin, Fu, Guofeng, Chen, Junyu, Wen, Yanling, Zhang, Wei, Pan, Bo-Sheng, Fang, Mujin, Zheng, Zizheng, Zhang, Zheng, Yuan, Quan, Fu, Guo, Li, Shaowei, Zhang, Jun, Chen, Yixin, Xia, Ningshao, Zhao, Qinjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967214/
https://www.ncbi.nlm.nih.gov/pubmed/35254215
http://dx.doi.org/10.1080/22221751.2022.2050951
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author Wang, Xin
Yin, Xiaochen
Zhang, Boya
Liu, Chenfeng
Lin, Yahua
Huang, Xiaofen
Li, Yufang
Shen, Chenguang
Zheng, Weibin
Fu, Guofeng
Chen, Junyu
Wen, Yanling
Zhang, Wei
Pan, Bo-Sheng
Fang, Mujin
Zheng, Zizheng
Zhang, Zheng
Yuan, Quan
Fu, Guo
Li, Shaowei
Zhang, Jun
Chen, Yixin
Xia, Ningshao
Zhao, Qinjian
author_facet Wang, Xin
Yin, Xiaochen
Zhang, Boya
Liu, Chenfeng
Lin, Yahua
Huang, Xiaofen
Li, Yufang
Shen, Chenguang
Zheng, Weibin
Fu, Guofeng
Chen, Junyu
Wen, Yanling
Zhang, Wei
Pan, Bo-Sheng
Fang, Mujin
Zheng, Zizheng
Zhang, Zheng
Yuan, Quan
Fu, Guo
Li, Shaowei
Zhang, Jun
Chen, Yixin
Xia, Ningshao
Zhao, Qinjian
author_sort Wang, Xin
collection PubMed
description Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses.
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spelling pubmed-89672142022-03-31 A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity Wang, Xin Yin, Xiaochen Zhang, Boya Liu, Chenfeng Lin, Yahua Huang, Xiaofen Li, Yufang Shen, Chenguang Zheng, Weibin Fu, Guofeng Chen, Junyu Wen, Yanling Zhang, Wei Pan, Bo-Sheng Fang, Mujin Zheng, Zizheng Zhang, Zheng Yuan, Quan Fu, Guo Li, Shaowei Zhang, Jun Chen, Yixin Xia, Ningshao Zhao, Qinjian Emerg Microbes Infect Influenza Infections Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses. Taylor & Francis 2022-03-28 /pmc/articles/PMC8967214/ /pubmed/35254215 http://dx.doi.org/10.1080/22221751.2022.2050951 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Influenza Infections
Wang, Xin
Yin, Xiaochen
Zhang, Boya
Liu, Chenfeng
Lin, Yahua
Huang, Xiaofen
Li, Yufang
Shen, Chenguang
Zheng, Weibin
Fu, Guofeng
Chen, Junyu
Wen, Yanling
Zhang, Wei
Pan, Bo-Sheng
Fang, Mujin
Zheng, Zizheng
Zhang, Zheng
Yuan, Quan
Fu, Guo
Li, Shaowei
Zhang, Jun
Chen, Yixin
Xia, Ningshao
Zhao, Qinjian
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
title A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
title_full A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
title_fullStr A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
title_full_unstemmed A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
title_short A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
title_sort prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
topic Influenza Infections
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967214/
https://www.ncbi.nlm.nih.gov/pubmed/35254215
http://dx.doi.org/10.1080/22221751.2022.2050951
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