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CHK1 phosphorylates PRIMPOL to promote replication stress tolerance

Replication-coupled DNA repair and damage tolerance mechanisms overcome replication stress challenges and complete DNA synthesis. These pathways include fork reversal, translesion synthesis, and repriming by specialized polymerases such as PRIMPOL. Here, we investigated how these pathways are used a...

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Detalles Bibliográficos
Autores principales:	Mehta, Kavi P. M., Thada, Vaughn, Zhao, Runxiang, Krishnamoorthy, Archana, Leser, Micheal, Lindsey Rose, Kristie, Cortez, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967226/ https://www.ncbi.nlm.nih.gov/pubmed/35353580 http://dx.doi.org/10.1126/sciadv.abm0314

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