Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model

Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here, we propose a hydrogel-based miRNA delivery strategy to rejuvenate impaired cartilage by creating a regenerative...

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Detalles Bibliográficos
Autores principales: Zhu, Jinjin, Yang, Shuhui, Qi, Yadong, Gong, Zhe, Zhang, Haitao, Liang, Kaiyu, Shen, Panyang, Huang, Yin-Yuan, Zhang, Zhe, Ye, Weilong, Yue, Lei, Fan, Shunwu, Shen, Shuying, Mikos, Antonios G., Wang, Xiumei, Fang, Xiangqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967232/
https://www.ncbi.nlm.nih.gov/pubmed/35353555
http://dx.doi.org/10.1126/sciadv.abk0011

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