Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo

Dynamic nuclear polarization (DNP) is a cutting-edge technique that markedly enhances the detection sensitivity of molecules using nuclear magnetic resonance (NMR)/magnetic resonance imaging (MRI). This methodology enables real-time imaging of dynamic metabolic status in vivo using MRI. To expand th...

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Detalles Bibliográficos
Autores principales: Saito, Yutaro, Yatabe, Hiroyuki, Tamura, Iori, Kondo, Yohei, Ishida, Ryo, Seki, Tomohiro, Hiraga, Keita, Eguchi, Akihiro, Takakusagi, Yoichi, Saito, Keisuke, Oshima, Nobu, Ishikita, Hiroshi, Yamamoto, Kazutoshi, Krishna, Murali C., Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967239/
https://www.ncbi.nlm.nih.gov/pubmed/35353577
http://dx.doi.org/10.1126/sciadv.abj2667

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