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Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly

Retinoic acid (RA) is a central signaling molecule regulating multiple developmental decisions during embryogenesis. Excess RA induces head malformations, primarily by expansion of posterior brain structures at the expense of anterior head regions, i.e., hindbrain expansion. Despite this extensively...

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Detalles Bibliográficos
Autores principales:	Gur, Michal, Bendelac-Kapon, Liat, Shabtai, Yehuda, Pillemer, Graciela, Fainsod, Abraham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967241/ https://www.ncbi.nlm.nih.gov/pubmed/35372345 http://dx.doi.org/10.3389/fcell.2022.844619

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