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Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening

Hematopoietic progenitor kinase (HPK1) is a negative regulator of T-cell receptor and B-cell signaling, which has been recognized as a novel antitumor target for immunotherapy. In this work, Glide docking-based virtual screening and kinase inhibition assay were performed to identify novel HPK1 inhib...

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Detalles Bibliográficos
Autores principales: Ge, Huizhen, Peng, Lizeng, Sun, Zhou, Liu, Huanxiang, Shen, Yulin, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967249/
https://www.ncbi.nlm.nih.gov/pubmed/35370676
http://dx.doi.org/10.3389/fphar.2022.850855

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