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Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study

PURPOSE: In this pilot study, the authors compared the effects of antioxidant co‐supplementation therapy and methylcobalamin therapy in patients with impaired semen quality. METHODS: Eighty‐four subjects who visited male infertility clinics and showed abnormal semen test results were randomly subjec...

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Autores principales: Yamasaki, Kazumitsu, Uchida, Masahiro, Watanabe, Noriko, Ihana, Tatsuji, Ishiguro, Yukari, Kuroda, Shinnosuke, Takeshima, Teppei, Yumura, Yasushi, Mieno, Makiko, Yoshida, Kaoru, Iwamoto, Teruaki, Nishiyama, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967282/
https://www.ncbi.nlm.nih.gov/pubmed/35386378
http://dx.doi.org/10.1002/rmb2.12450
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author Yamasaki, Kazumitsu
Uchida, Masahiro
Watanabe, Noriko
Ihana, Tatsuji
Ishiguro, Yukari
Kuroda, Shinnosuke
Takeshima, Teppei
Yumura, Yasushi
Mieno, Makiko
Yoshida, Kaoru
Iwamoto, Teruaki
Nishiyama, Hiroyuki
author_facet Yamasaki, Kazumitsu
Uchida, Masahiro
Watanabe, Noriko
Ihana, Tatsuji
Ishiguro, Yukari
Kuroda, Shinnosuke
Takeshima, Teppei
Yumura, Yasushi
Mieno, Makiko
Yoshida, Kaoru
Iwamoto, Teruaki
Nishiyama, Hiroyuki
author_sort Yamasaki, Kazumitsu
collection PubMed
description PURPOSE: In this pilot study, the authors compared the effects of antioxidant co‐supplementation therapy and methylcobalamin therapy in patients with impaired semen quality. METHODS: Eighty‐four subjects who visited male infertility clinics and showed abnormal semen test results were randomly subjected to one of the two therapies: antioxidant co‐supplementation therapy with vitamin C, vitamin E, coenzyme Q10, and flaxseed oil or methylcobalamin therapy. The oxidation–reduction potential (ORP) and 8‐hydroxy‐2′‐deoxyguanosine levels were used as indicators of oxidative stress levels in semen. Semen analysis was also performed. RESULTS: The authors obtained results from 67 patients who had completed 3 months of treatment. Neither antioxidant co‐supplementation therapy nor methylcobalamin therapy changed the semen parameters significantly (except for the sperm concentration, which was increased by the latter therapy). When the pre‐treatment ORP value in semen was higher than the cutoff value, both therapies significantly increased the sperm concentration. The 8‐hydroxy‐2′‐deoxyguanosine level did not yield any meaningful predictive value with regard to increased sperm concentrations. CONCLUSIONS: Both antioxidant co‐supplementation therapy and methylcobalamin therapy increased the sperm concentration in patients with impaired semen quality when the basal ORP levels in their semen were elevated.
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spelling pubmed-89672822022-04-05 Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study Yamasaki, Kazumitsu Uchida, Masahiro Watanabe, Noriko Ihana, Tatsuji Ishiguro, Yukari Kuroda, Shinnosuke Takeshima, Teppei Yumura, Yasushi Mieno, Makiko Yoshida, Kaoru Iwamoto, Teruaki Nishiyama, Hiroyuki Reprod Med Biol Original Article PURPOSE: In this pilot study, the authors compared the effects of antioxidant co‐supplementation therapy and methylcobalamin therapy in patients with impaired semen quality. METHODS: Eighty‐four subjects who visited male infertility clinics and showed abnormal semen test results were randomly subjected to one of the two therapies: antioxidant co‐supplementation therapy with vitamin C, vitamin E, coenzyme Q10, and flaxseed oil or methylcobalamin therapy. The oxidation–reduction potential (ORP) and 8‐hydroxy‐2′‐deoxyguanosine levels were used as indicators of oxidative stress levels in semen. Semen analysis was also performed. RESULTS: The authors obtained results from 67 patients who had completed 3 months of treatment. Neither antioxidant co‐supplementation therapy nor methylcobalamin therapy changed the semen parameters significantly (except for the sperm concentration, which was increased by the latter therapy). When the pre‐treatment ORP value in semen was higher than the cutoff value, both therapies significantly increased the sperm concentration. The 8‐hydroxy‐2′‐deoxyguanosine level did not yield any meaningful predictive value with regard to increased sperm concentrations. CONCLUSIONS: Both antioxidant co‐supplementation therapy and methylcobalamin therapy increased the sperm concentration in patients with impaired semen quality when the basal ORP levels in their semen were elevated. John Wiley and Sons Inc. 2022-02-27 /pmc/articles/PMC8967282/ /pubmed/35386378 http://dx.doi.org/10.1002/rmb2.12450 Text en © 2022 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yamasaki, Kazumitsu
Uchida, Masahiro
Watanabe, Noriko
Ihana, Tatsuji
Ishiguro, Yukari
Kuroda, Shinnosuke
Takeshima, Teppei
Yumura, Yasushi
Mieno, Makiko
Yoshida, Kaoru
Iwamoto, Teruaki
Nishiyama, Hiroyuki
Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
title Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
title_full Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
title_fullStr Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
title_full_unstemmed Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
title_short Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
title_sort effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967282/
https://www.ncbi.nlm.nih.gov/pubmed/35386378
http://dx.doi.org/10.1002/rmb2.12450
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