The APOE(ε3/ε4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

INTRODUCTION: Restrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer’s disease (AD) and dementia, APOE(ε4), by hindering observation of a key, common genotype in humans – APOE(ε3/ε4). Human studies are typica...

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Detalles Bibliográficos
Autores principales: Foley, Kate E., Hewes, Amanda A., Garceau, Dylan T., Kotredes, Kevin P., Carter, Gregory W., Sasner, Michael, Howell, Gareth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967347/
https://www.ncbi.nlm.nih.gov/pubmed/35370604
http://dx.doi.org/10.3389/fnagi.2022.838436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967347/
https://www.ncbi.nlm.nih.gov/pubmed/35370604
http://dx.doi.org/10.3389/fnagi.2022.838436

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