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Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris
BACKGROUND: Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD). Traditional Chinese medi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967507/ https://www.ncbi.nlm.nih.gov/pubmed/35368765 http://dx.doi.org/10.1155/2022/4321298 |
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author | Yang, Chih-Hui Kuo, Wen-Shuo Wang, Jun-Sheng Hsiang, Yi-Ping Lin, Yu-Mei Wang, Yi-Ting Tsai, Fan-Hsuan Lee, Chun-Ting Chou, Jiun-Hua Chang, Huei-Ya Wang, Lung-Shuo Wang, Shu-Chi Huang, Keng-Shiang |
author_facet | Yang, Chih-Hui Kuo, Wen-Shuo Wang, Jun-Sheng Hsiang, Yi-Ping Lin, Yu-Mei Wang, Yi-Ting Tsai, Fan-Hsuan Lee, Chun-Ting Chou, Jiun-Hua Chang, Huei-Ya Wang, Lung-Shuo Wang, Shu-Chi Huang, Keng-Shiang |
author_sort | Yang, Chih-Hui |
collection | PubMed |
description | BACKGROUND: Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD). Traditional Chinese medicine practices have shown that Cordyceps militaris (C. militaris) mycelia have a variety of pharmacologically useful properties, including antitumor, immunomodulation, and hepatoprotection. However, the effect of mycelial C. militaris on CKD remains unclear. METHODS: Here, we investigated the effects of C. militaris mycelia on mice with CKD using four types of media: HKS, HKS with vitamin A (HKS + A), CM, and CM with vitamin A (CM + A). RESULTS: The results at day 10 revealed that the levels of blood urea nitrogen (BUN) were significantly lower in the HKS (41%), HKS + A (41%), and CM + A (34%) groups compared with those in the corresponding control groups (nephrectomic mice). The level of serum creatinine in the HKS + A group decreased by 35% at day 10, whereas the levels in the HKS and CM + A groups decreased only by 14% and 13%, respectively, on day 30. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effect on BUN, serum creatinine, body weight, total protein, and uric acid. CONCLUSIONS: Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effects on BUN, serum creatinine, body weight, total protein, and uric acid. We concluded that treatment with C. militaris mycelia cultured in HKS or CM + A medium could potentially prevent the deterioration of kidney function in mice with CKD. |
format | Online Article Text |
id | pubmed-8967507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89675072022-03-31 Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris Yang, Chih-Hui Kuo, Wen-Shuo Wang, Jun-Sheng Hsiang, Yi-Ping Lin, Yu-Mei Wang, Yi-Ting Tsai, Fan-Hsuan Lee, Chun-Ting Chou, Jiun-Hua Chang, Huei-Ya Wang, Lung-Shuo Wang, Shu-Chi Huang, Keng-Shiang Evid Based Complement Alternat Med Research Article BACKGROUND: Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD). Traditional Chinese medicine practices have shown that Cordyceps militaris (C. militaris) mycelia have a variety of pharmacologically useful properties, including antitumor, immunomodulation, and hepatoprotection. However, the effect of mycelial C. militaris on CKD remains unclear. METHODS: Here, we investigated the effects of C. militaris mycelia on mice with CKD using four types of media: HKS, HKS with vitamin A (HKS + A), CM, and CM with vitamin A (CM + A). RESULTS: The results at day 10 revealed that the levels of blood urea nitrogen (BUN) were significantly lower in the HKS (41%), HKS + A (41%), and CM + A (34%) groups compared with those in the corresponding control groups (nephrectomic mice). The level of serum creatinine in the HKS + A group decreased by 35% at day 10, whereas the levels in the HKS and CM + A groups decreased only by 14% and 13%, respectively, on day 30. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effect on BUN, serum creatinine, body weight, total protein, and uric acid. CONCLUSIONS: Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effects on BUN, serum creatinine, body weight, total protein, and uric acid. We concluded that treatment with C. militaris mycelia cultured in HKS or CM + A medium could potentially prevent the deterioration of kidney function in mice with CKD. Hindawi 2022-03-23 /pmc/articles/PMC8967507/ /pubmed/35368765 http://dx.doi.org/10.1155/2022/4321298 Text en Copyright © 2022 Chih-Hui Yang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Chih-Hui Kuo, Wen-Shuo Wang, Jun-Sheng Hsiang, Yi-Ping Lin, Yu-Mei Wang, Yi-Ting Tsai, Fan-Hsuan Lee, Chun-Ting Chou, Jiun-Hua Chang, Huei-Ya Wang, Lung-Shuo Wang, Shu-Chi Huang, Keng-Shiang Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris |
title | Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris |
title_full | Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris |
title_fullStr | Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris |
title_full_unstemmed | Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris |
title_short | Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris |
title_sort | improvement in the blood urea nitrogen and serum creatinine using new cultivation of cordyceps militaris |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967507/ https://www.ncbi.nlm.nih.gov/pubmed/35368765 http://dx.doi.org/10.1155/2022/4321298 |
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