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Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance
Combined antiretroviral therapy (cART) can inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and reduce viral loads in the peripheral blood to undetectable levels. However, the presence of latent HIV-1 reservoirs prevents complete HIV-1 eradication. Several drugs and strategies...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967654/ https://www.ncbi.nlm.nih.gov/pubmed/35371060 http://dx.doi.org/10.3389/fimmu.2022.842746 |
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author | Duan, Siqin Liu, Shuwen |
author_facet | Duan, Siqin Liu, Shuwen |
author_sort | Duan, Siqin |
collection | PubMed |
description | Combined antiretroviral therapy (cART) can inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and reduce viral loads in the peripheral blood to undetectable levels. However, the presence of latent HIV-1 reservoirs prevents complete HIV-1 eradication. Several drugs and strategies targeting T cells are now in clinical trials, but their effectiveness in reducing viral reservoirs has been mixed. Interestingly, innate immune natural killer (NK) cells, which are promising targets for cancer therapy, also play an important role in HIV-1 infection. NK cells are a unique innate cell population with features of adaptive immunity that can regulate adaptive and innate immune cell populations; therefore, they can be exploited for HIV-1 immunotherapy and reservoir eradication. In this review, we highlight immunotherapy strategies for HIV infection that utilize the beneficial properties of NK cells. |
format | Online Article Text |
id | pubmed-8967654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89676542022-03-31 Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance Duan, Siqin Liu, Shuwen Front Immunol Immunology Combined antiretroviral therapy (cART) can inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and reduce viral loads in the peripheral blood to undetectable levels. However, the presence of latent HIV-1 reservoirs prevents complete HIV-1 eradication. Several drugs and strategies targeting T cells are now in clinical trials, but their effectiveness in reducing viral reservoirs has been mixed. Interestingly, innate immune natural killer (NK) cells, which are promising targets for cancer therapy, also play an important role in HIV-1 infection. NK cells are a unique innate cell population with features of adaptive immunity that can regulate adaptive and innate immune cell populations; therefore, they can be exploited for HIV-1 immunotherapy and reservoir eradication. In this review, we highlight immunotherapy strategies for HIV infection that utilize the beneficial properties of NK cells. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8967654/ /pubmed/35371060 http://dx.doi.org/10.3389/fimmu.2022.842746 Text en Copyright © 2022 Duan and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Duan, Siqin Liu, Shuwen Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance |
title | Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance |
title_full | Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance |
title_fullStr | Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance |
title_full_unstemmed | Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance |
title_short | Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance |
title_sort | targeting nk cells for hiv-1 treatment and reservoir clearance |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967654/ https://www.ncbi.nlm.nih.gov/pubmed/35371060 http://dx.doi.org/10.3389/fimmu.2022.842746 |
work_keys_str_mv | AT duansiqin targetingnkcellsforhiv1treatmentandreservoirclearance AT liushuwen targetingnkcellsforhiv1treatmentandreservoirclearance |