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The role of E-Cadherin expression in primary site of breast cancer

PURPOSE: The tumour’s ability to metastasize is the major cause for fatal outcomes in cancer diseases. In breast cancer, aberrant E-Cadherin expression has been linked to invasiveness and poor prognosis. METHOD: We assessed expression of E-Cadherin by immunohistochemistry in primary tumour tissue fr...

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Detalles Bibliográficos
Autores principales: Karsten, Nora, Kolben, Thomas, Mahner, Sven, Beyer, Susanne, Meister, Sarah, Kuhn, Christina, Schmoeckel, Elisa, Wuerstlein, Rachel, Harbeck, Nadia, Ditsch, Nina, Jeschke, Udo, Friese, Klaus, Kolben, Theresa Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967771/
https://www.ncbi.nlm.nih.gov/pubmed/34510244
http://dx.doi.org/10.1007/s00404-021-06198-1
Descripción
Sumario:PURPOSE: The tumour’s ability to metastasize is the major cause for fatal outcomes in cancer diseases. In breast cancer, aberrant E-Cadherin expression has been linked to invasiveness and poor prognosis. METHOD: We assessed expression of E-Cadherin by immunohistochemistry in primary tumour tissue from 125 female breast cancer patients. Staining intensities were analysed using the immunoreactive score (IRS). We investigated E-Cadherin expression and its associations with clinicopathological parameters (age, tumour size, lymph node status, grade, hormone receptors, Her2 Status) as well as with recurrence and survival. RESULTS: Increased, rather than aberrant E-Cadherin expression was found and was associated with poor outcome (p = 0.046). Our data show an association between elevated E-Cadherin in primary tumour tissue and an unfavourable negative prognosis in patients. CONCLUSION: This association was somehow unexpected as loss of E-Cadherin has long been regarded as a prerequisite for development of invasiveness and metastases. Our findings support the notion that E-Cadherin promotes, rather than suppresses, development of metastasis and invasiveness.