Cargando…
Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory
BACKGROUND: Prior studies of early antibiotic use and growth have shown mixed results, primarily on cross-sectional outcomes. This study examined the effect of oral antibiotics before age 24 months on growth trajectory at age 2–5 years. METHODS: We captured oral antibiotic prescriptions and anthropo...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967797/ https://www.ncbi.nlm.nih.gov/pubmed/34999718 http://dx.doi.org/10.1038/s41366-021-01023-w |
_version_ | 1784678904530731008 |
---|---|
author | Bailey, L. Charles Bryan, Matthew Maltenfort, Mitchell Block, Jason P. Teneralli, Rachel Lunsford, Douglas Boone-Heinonen, Janne Eneli, Ihuoma Horgan, Casie E. Lin, Pi-I D. Reynolds, Juliane S. Solomonides, Anthony E. Janicke, David Sturtevant, Jessica L. Toh, Sengwee Taveras, Elsie Appelhans, Bradley M. Arterburn, David Daley, Matthew F. Dempsey, Amanda Dugas, Lara R. Finkelstein, Jonathan Fitzpatrick, Stephanie L. Goodman, Andrea Gurka, Matthew J. Heerman, William J. Horberg, Michael Hossain, Md Jobbayer Hsia, Daniel S. Isasi, Carmen R. Kharbanda, Elyse O. Messito, Mary Jo Murphy, Kathleen O’Bryan, Kevin Peay, Holly L. Prochaska, Micah T. Puro, Jon Rayas, Maria Rosenman, Marc B. Taylor, Bradley VanWormer, Jeffrey J. Willis, Zachary Yeramaneni, Samrat |
author_facet | Bailey, L. Charles Bryan, Matthew Maltenfort, Mitchell Block, Jason P. Teneralli, Rachel Lunsford, Douglas Boone-Heinonen, Janne Eneli, Ihuoma Horgan, Casie E. Lin, Pi-I D. Reynolds, Juliane S. Solomonides, Anthony E. Janicke, David Sturtevant, Jessica L. Toh, Sengwee Taveras, Elsie Appelhans, Bradley M. Arterburn, David Daley, Matthew F. Dempsey, Amanda Dugas, Lara R. Finkelstein, Jonathan Fitzpatrick, Stephanie L. Goodman, Andrea Gurka, Matthew J. Heerman, William J. Horberg, Michael Hossain, Md Jobbayer Hsia, Daniel S. Isasi, Carmen R. Kharbanda, Elyse O. Messito, Mary Jo Murphy, Kathleen O’Bryan, Kevin Peay, Holly L. Prochaska, Micah T. Puro, Jon Rayas, Maria Rosenman, Marc B. Taylor, Bradley VanWormer, Jeffrey J. Willis, Zachary Yeramaneni, Samrat |
author_sort | Bailey, L. Charles |
collection | PubMed |
description | BACKGROUND: Prior studies of early antibiotic use and growth have shown mixed results, primarily on cross-sectional outcomes. This study examined the effect of oral antibiotics before age 24 months on growth trajectory at age 2–5 years. METHODS: We captured oral antibiotic prescriptions and anthropometrics from electronic health records through PCORnet, for children with ≥1 height and weight at 0–12 months of age, ≥1 at 12–30 months, and ≥2 between 25 and 72 months. Prescriptions were grouped into episodes by time and by antimicrobial spectrum. Longitudinal rate regression was used to assess differences in growth rate from 25 to 72 months of age. Models were adjusted for sex, race/ethnicity, steroid use, diagnosed asthma, complex chronic conditions, and infections. RESULTS: 430,376 children from 29 health U.S. systems were included, with 58% receiving antibiotics before 24 months. Exposure to any antibiotic was associated with an average 0.7% (95% CI 0.5, 0.9, p < 0.0001) greater rate of weight gain, corresponding to 0.05 kg additional weight. The estimated effect was slightly greater for narrow-spectrum (0.8% [0.6, 1.1]) than broad-spectrum (0.6% [0.3, 0.8], p < 0.0001) drugs. There was a small dose response relationship between the number of antibiotic episodes and weight gain. CONCLUSION: Oral antibiotic use prior to 24 months of age was associated with very small changes in average growth rate at ages 2–5 years. The small effect size is unlikely to affect individual prescribing decisions, though it may reflect a biologic effect that can combine with others. |
format | Online Article Text |
id | pubmed-8967797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-89677972022-07-08 Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory Bailey, L. Charles Bryan, Matthew Maltenfort, Mitchell Block, Jason P. Teneralli, Rachel Lunsford, Douglas Boone-Heinonen, Janne Eneli, Ihuoma Horgan, Casie E. Lin, Pi-I D. Reynolds, Juliane S. Solomonides, Anthony E. Janicke, David Sturtevant, Jessica L. Toh, Sengwee Taveras, Elsie Appelhans, Bradley M. Arterburn, David Daley, Matthew F. Dempsey, Amanda Dugas, Lara R. Finkelstein, Jonathan Fitzpatrick, Stephanie L. Goodman, Andrea Gurka, Matthew J. Heerman, William J. Horberg, Michael Hossain, Md Jobbayer Hsia, Daniel S. Isasi, Carmen R. Kharbanda, Elyse O. Messito, Mary Jo Murphy, Kathleen O’Bryan, Kevin Peay, Holly L. Prochaska, Micah T. Puro, Jon Rayas, Maria Rosenman, Marc B. Taylor, Bradley VanWormer, Jeffrey J. Willis, Zachary Yeramaneni, Samrat Int J Obes (Lond) Article BACKGROUND: Prior studies of early antibiotic use and growth have shown mixed results, primarily on cross-sectional outcomes. This study examined the effect of oral antibiotics before age 24 months on growth trajectory at age 2–5 years. METHODS: We captured oral antibiotic prescriptions and anthropometrics from electronic health records through PCORnet, for children with ≥1 height and weight at 0–12 months of age, ≥1 at 12–30 months, and ≥2 between 25 and 72 months. Prescriptions were grouped into episodes by time and by antimicrobial spectrum. Longitudinal rate regression was used to assess differences in growth rate from 25 to 72 months of age. Models were adjusted for sex, race/ethnicity, steroid use, diagnosed asthma, complex chronic conditions, and infections. RESULTS: 430,376 children from 29 health U.S. systems were included, with 58% receiving antibiotics before 24 months. Exposure to any antibiotic was associated with an average 0.7% (95% CI 0.5, 0.9, p < 0.0001) greater rate of weight gain, corresponding to 0.05 kg additional weight. The estimated effect was slightly greater for narrow-spectrum (0.8% [0.6, 1.1]) than broad-spectrum (0.6% [0.3, 0.8], p < 0.0001) drugs. There was a small dose response relationship between the number of antibiotic episodes and weight gain. CONCLUSION: Oral antibiotic use prior to 24 months of age was associated with very small changes in average growth rate at ages 2–5 years. The small effect size is unlikely to affect individual prescribing decisions, though it may reflect a biologic effect that can combine with others. 2022-04 2022-01-08 /pmc/articles/PMC8967797/ /pubmed/34999718 http://dx.doi.org/10.1038/s41366-021-01023-w Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms |
spellingShingle | Article Bailey, L. Charles Bryan, Matthew Maltenfort, Mitchell Block, Jason P. Teneralli, Rachel Lunsford, Douglas Boone-Heinonen, Janne Eneli, Ihuoma Horgan, Casie E. Lin, Pi-I D. Reynolds, Juliane S. Solomonides, Anthony E. Janicke, David Sturtevant, Jessica L. Toh, Sengwee Taveras, Elsie Appelhans, Bradley M. Arterburn, David Daley, Matthew F. Dempsey, Amanda Dugas, Lara R. Finkelstein, Jonathan Fitzpatrick, Stephanie L. Goodman, Andrea Gurka, Matthew J. Heerman, William J. Horberg, Michael Hossain, Md Jobbayer Hsia, Daniel S. Isasi, Carmen R. Kharbanda, Elyse O. Messito, Mary Jo Murphy, Kathleen O’Bryan, Kevin Peay, Holly L. Prochaska, Micah T. Puro, Jon Rayas, Maria Rosenman, Marc B. Taylor, Bradley VanWormer, Jeffrey J. Willis, Zachary Yeramaneni, Samrat Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory |
title | Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory |
title_full | Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory |
title_fullStr | Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory |
title_full_unstemmed | Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory |
title_short | Antibiotics Prior to Age Two Years Have Limited Association with Preschool Growth Trajectory |
title_sort | antibiotics prior to age two years have limited association with preschool growth trajectory |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967797/ https://www.ncbi.nlm.nih.gov/pubmed/34999718 http://dx.doi.org/10.1038/s41366-021-01023-w |
work_keys_str_mv | AT baileylcharles antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT bryanmatthew antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT maltenfortmitchell antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT blockjasonp antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT tenerallirachel antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT lunsforddouglas antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT booneheinonenjanne antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT eneliihuoma antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT horgancasiee antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT linpiid antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT reynoldsjulianes antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT solomonidesanthonye antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT janickedavid antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT sturtevantjessical antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT tohsengwee antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT taveraselsie antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT appelhansbradleym antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT arterburndavid antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT daleymatthewf antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT dempseyamanda antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT dugaslarar antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT finkelsteinjonathan antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT fitzpatrickstephaniel antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT goodmanandrea antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT gurkamatthewj antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT heermanwilliamj antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT horbergmichael antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT hossainmdjobbayer antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT hsiadaniels antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT isasicarmenr antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT kharbandaelyseo antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT messitomaryjo antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT murphykathleen antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT obryankevin antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT peayhollyl antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT prochaskamicaht antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT purojon antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT rayasmaria antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT rosenmanmarcb antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT taylorbradley antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT vanwormerjeffreyj antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT williszachary antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT yeramanenisamrat antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory AT antibioticspriortoagetwoyearshavelimitedassociationwithpreschoolgrowthtrajectory |