Cargando…

Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome

Tourette’s Syndrome (TS) is a neurodevelopmental disorder that is characterized by motor and phonic tics. A recent TS genome-wide association study (GWAS) identified a genome-wide significant locus. However, determining the biological mechanism of GWAS signals remains difficult. To characterize effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Calwing, Vuokila, Veikko, Catoire, Hélène, Akçimen, Fulya, Ross, Jay P., Bourassa, Cynthia V., Dion, Patrick A., Meijer, Inge A., Rouleau, Guy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967882/ https://www.ncbi.nlm.nih.gov/pubmed/35354918 http://dx.doi.org/10.1038/s42003-022-03231-0

Ejemplares similares

Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor
por: Liao, Calwing, et al.
Publicado: (2020)

Transcriptome-wide association study for restless legs syndrome identifies new susceptibility genes
por: Akçimen, Fulya, et al.
Publicado: (2020)

Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
por: Liao, Calwing, et al.
Publicado: (2019)

Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph disease
por: Akçimen, Fulya, et al.
Publicado: (2020)

Questioning the Association of the STMN2 Dinucleotide Repeat With Amyotrophic Lateral Sclerosis
por: Ross, Jay P., et al.
Publicado: (2022)

Investigation of the RFC1 Repeat Expansion in a Canadian and a Brazilian Ataxia Cohort: Identification of Novel Conformations
por: Akçimen, Fulya, et al.
Publicado: (2019)

Progress in the genetics of restless legs syndrome: the path ahead in the era of whole-genome sequencing
por: Akçimen, Fulya, et al.
Publicado: (2022)

Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
por: Sarayloo, Faezeh, et al.
Publicado: (2019)

Screening of novel restless legs syndrome–associated genes in French-Canadian families
por: Akçimen, Fulya, et al.
Publicado: (2018)

Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis
por: Liao, Calwing, et al.
Publicado: (2022)

Genome-wide association study of Tourette Syndrome
por: Scharf, Jeremiah M., et al.
Publicado: (2012)

Somatic expansion of the C9orf72 hexanucleotide repeat does not occur in ALS spinal cord tissues
por: Ross, Jay P., et al.
Publicado: (2019)

Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population
por: Zhou, Sirui, et al.
Publicado: (2018)

Transcriptomic effects of propranolol and primidone converge on molecular pathways relevant to essential tremor
por: Castonguay, Charles-Etienne, et al.
Publicado: (2022)

Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids
por: Tamaki, Yoshitaka, et al.
Publicado: (2023)

Exome sequencing in genetic disease: recent advances and considerations
por: Ross, Jay P., et al.
Publicado: (2020)

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia
por: Merner, Nancy D., et al.
Publicado: (2015)

GBA p.T369M substitution in Parkinson disease: Polymorphism or association? A meta-analysis
por: Mallett, Victoria, et al.
Publicado: (2016)

Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome
por: Jain, Pritesh, et al.
Publicado: (2023)

Genome-wide sequencing for the identification of rearrangements associated with Tourette syndrome and obsessive-compulsive disorder
por: Hooper, Sean D, et al.
Publicado: (2012)

A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1
por: Catoire, Helene, et al.
Publicado: (2018)

LINGO1 Variants in the French-Canadian Population
por: Bourassa, Cynthia V., et al.
Publicado: (2011)

Deutetrabenazine in Tics Associated with Tourette Syndrome
por: Jankovic, Joseph, et al.
Publicado: (2016)

The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods
por: Dietrich, Andrea, et al.
Publicado: (2014)

The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
por: Sun, Nawei, et al.
Publicado: (2017)

Functional Evaluations of Genes Disrupted in Patients with Tourette’s Disorder
por: Sun, Nawei, et al.
Publicado: (2016)

Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5–PKC signalling in mouse cortical neurons
por: Khayachi, Anouar, et al.
Publicado: (2021)

Whole exome sequencing identifies genes associated with Tourette’s Disorder in multiplex families
por: Cao, Xiaolong, et al.
Publicado: (2021)

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes
por: Alfradique-Dunham, Isabel, et al.
Publicado: (2021)

Synaptic processes and immune-related pathways implicated in Tourette syndrome
por: Tsetsos, Fotis, et al.
Publicado: (2021)

Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study
por: Alipour, Paria, et al.
Publicado: (2022)

Urge-tic associations in children and adolescents with Tourette syndrome
por: Langelage, Jennifer, et al.
Publicado: (2022)

No rare deleterious variants from STK32B, PPARGC1A, and CTNNA3 are associated with essential tremor
por: Houle, Gabrielle, et al.
Publicado: (2017)

Increased Missense Mutation Burden of Fatty Acid Metabolism Related Genes in Nunavik Inuit Population
por: Zhou, Sirui, et al.
Publicado: (2015)

Mutation Burden of Rare Variants in Schizophrenia Candidate Genes
por: Girard, Simon L., et al.
Publicado: (2015)

Are there distinct subtypes in Tourette syndrome? Pure-Tourette syndrome versus Tourette syndrome-plus, and simple versus complex tics
por: Eapen, Valsamma, et al.
Publicado: (2015)

New Jersey Center for Tourette Syndrome Sharing Repository: methods and sample description
por: Heiman, Gary A, et al.
Publicado: (2008)

The Impact of Phenotypic and Genetic Heterogeneity on Results of Genome Wide Association Studies of Complex Diseases
por: Manchia, Mirko, et al.
Publicado: (2013)

Tourette's disorder and associated complex behaviors: a case report.
por: McDougle, C. J., et al.
Publicado: (1990)

Impairment of visually guided associative learning in children with Tourette syndrome
por: Eördegh, Gabriella, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bo8v66agkph6hrjnrm41i5voei