Tuberculosis‐immune reconstitution inflammatory syndrome in HIV‐negative children

Even though tuberculosis‐immune reconstitution inflammatory syndrome (TB‐IRIS) is usually found in HIV‐positive patients receiving antiviral treatment, it can also occur in HIV‐negative patients especially if they have risk factors. We report a unique case of TB‐IRIS in an immunocompetent child presenting with new onset of pleuritic chest pain after receiving anti‐TB drugs. TB‐IRIS should be considered as a differential diagnosis in case of clinical deterioration or appearance of new typical lesions despite appropriate anti‐TB treatment for more than 2 weeks in the absence of persistently active TB or any other alternative causes. This will prevent physicians from misdiagnosis as superimposed infections, treatment failure or TB relapse.