Cargando…
Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels. However, most of these drugs do not provide sufficient specificity to a sin...
Autores principales: | Wisedchaisri, Goragot, Gamal El-Din, Tamer M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968173/ https://www.ncbi.nlm.nih.gov/pubmed/35370700 http://dx.doi.org/10.3389/fphar.2022.858348 |
Ejemplares similares
-
Editorial: Structure Related Druggability of Voltage-Gated Sodium and Calcium Ion-Channels to Treat Diseases
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022) -
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na(V)1.7
por: Wisedchaisri, Goragot, et al.
Publicado: (2023) -
Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022) -
Structural Advances in Voltage-Gated Sodium Channels
por: Jiang, Daohua, et al.
Publicado: (2022) -
Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
por: Stevens, Marijke, et al.
Publicado: (2011)