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Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets
Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interph...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association of Anatomists
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968224/ https://www.ncbi.nlm.nih.gov/pubmed/35354673 http://dx.doi.org/10.5115/acb.21.227 |
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author | Kim, Jeongtae Chun, Jiyoon Ahn, Meejung Jung, Kyungsook Moon, Changjong Shin, Taekyun |
author_facet | Kim, Jeongtae Chun, Jiyoon Ahn, Meejung Jung, Kyungsook Moon, Changjong Shin, Taekyun |
author_sort | Kim, Jeongtae |
collection | PubMed |
description | Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interphotoreceptor retinoid-binding proteins, in Lewis rats. The pathogenesis of EAU in rats involves the proliferation of autoimmune T cells in peripheral lymphoid tissues and breakdown of the blood-retinal barrier, primarily in the uvea and retina, finally inducing visual dysfunction. In this review, we describe recent EAU studies to facilitate the design of a therapeutic strategy through the interruption of uveitogenic factors during the course of EAU, which will be helpful for controlling human uveitis. |
format | Online Article Text |
id | pubmed-8968224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Association of Anatomists |
record_format | MEDLINE/PubMed |
spelling | pubmed-89682242022-04-05 Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets Kim, Jeongtae Chun, Jiyoon Ahn, Meejung Jung, Kyungsook Moon, Changjong Shin, Taekyun Anat Cell Biol Review Article Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interphotoreceptor retinoid-binding proteins, in Lewis rats. The pathogenesis of EAU in rats involves the proliferation of autoimmune T cells in peripheral lymphoid tissues and breakdown of the blood-retinal barrier, primarily in the uvea and retina, finally inducing visual dysfunction. In this review, we describe recent EAU studies to facilitate the design of a therapeutic strategy through the interruption of uveitogenic factors during the course of EAU, which will be helpful for controlling human uveitis. Korean Association of Anatomists 2022-03-31 2022-03-31 /pmc/articles/PMC8968224/ /pubmed/35354673 http://dx.doi.org/10.5115/acb.21.227 Text en Copyright © 2022. Anatomy & Cell Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kim, Jeongtae Chun, Jiyoon Ahn, Meejung Jung, Kyungsook Moon, Changjong Shin, Taekyun Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
title | Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
title_full | Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
title_fullStr | Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
title_full_unstemmed | Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
title_short | Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
title_sort | blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968224/ https://www.ncbi.nlm.nih.gov/pubmed/35354673 http://dx.doi.org/10.5115/acb.21.227 |
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