Lung parenchymal calcifications in a child with cystic fibrosis

We describe a 6‐year‐old girl with homozygous p.Phe508del cystic fibrosis with severe multi‐lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcif...

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Autores principales: Lynch, Heidi, Qian, Frank, Wong, Matthew D., Thomas, Rahul J., Kapur, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968259/
https://www.ncbi.nlm.nih.gov/pubmed/35386578
http://dx.doi.org/10.1002/rcr2.941
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author Lynch, Heidi
Qian, Frank
Wong, Matthew D.
Thomas, Rahul J.
Kapur, Nitin
author_facet Lynch, Heidi
Qian, Frank
Wong, Matthew D.
Thomas, Rahul J.
Kapur, Nitin
author_sort Lynch, Heidi
collection PubMed
description We describe a 6‐year‐old girl with homozygous p.Phe508del cystic fibrosis with severe multi‐lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcified area of lung biopsy showed fibrous tissue with chronic inflammation with CD3+ T‐lymphocytes and macrophages with no granulomas. Dystrophic calcification was seen within this necrotic debris.
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spelling pubmed-89682592022-04-05 Lung parenchymal calcifications in a child with cystic fibrosis Lynch, Heidi Qian, Frank Wong, Matthew D. Thomas, Rahul J. Kapur, Nitin Respirol Case Rep Case Reports We describe a 6‐year‐old girl with homozygous p.Phe508del cystic fibrosis with severe multi‐lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcified area of lung biopsy showed fibrous tissue with chronic inflammation with CD3+ T‐lymphocytes and macrophages with no granulomas. Dystrophic calcification was seen within this necrotic debris. John Wiley & Sons, Ltd 2022-03-31 /pmc/articles/PMC8968259/ /pubmed/35386578 http://dx.doi.org/10.1002/rcr2.941 Text en © 2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Lynch, Heidi
Qian, Frank
Wong, Matthew D.
Thomas, Rahul J.
Kapur, Nitin
Lung parenchymal calcifications in a child with cystic fibrosis
title Lung parenchymal calcifications in a child with cystic fibrosis
title_full Lung parenchymal calcifications in a child with cystic fibrosis
title_fullStr Lung parenchymal calcifications in a child with cystic fibrosis
title_full_unstemmed Lung parenchymal calcifications in a child with cystic fibrosis
title_short Lung parenchymal calcifications in a child with cystic fibrosis
title_sort lung parenchymal calcifications in a child with cystic fibrosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968259/
https://www.ncbi.nlm.nih.gov/pubmed/35386578
http://dx.doi.org/10.1002/rcr2.941
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AT thomasrahulj lungparenchymalcalcificationsinachildwithcysticfibrosis
AT kapurnitin lungparenchymalcalcificationsinachildwithcysticfibrosis

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