Probable Vanishing White Matter Disease: A Case Report and Literature Review

BACKGROUND: Vanishing white matter disease is one of the most prevalent inherited childhood leukoencephalopathies. The disease is characterized by chronic, progressive and episodic deterioration with ataxia and spasticity. CASE PRESENTATION: Here, we report a 15-month-old female child from Dire-Dawa...

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Detalles Bibliográficos
Autores principales: Deginet, Endayen, Tilahun, Robel, Bishaw, Solomon, Eshetu, Konjit, Moges, Ayalew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Publications Office of Jimma University 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968366/
https://www.ncbi.nlm.nih.gov/pubmed/35392331
http://dx.doi.org/10.4314/ejhs.v31i6.28
Descripción
Sumario:BACKGROUND: Vanishing white matter disease is one of the most prevalent inherited childhood leukoencephalopathies. The disease is characterized by chronic, progressive and episodic deterioration with ataxia and spasticity. CASE PRESENTATION: Here, we report a 15-month-old female child from Dire-Dawa, eastern part of Ethiopia, who presented with regression of developmental milestones and truncal ataxia since her age of 11 months following a febrile illness that occurred one month earlier. Magnetic resonance imaging of brain is suggestive of vanishing white matter disease. CONCLUSIONS: We believe this case report will increase curiosity, awareness and knowledge of health professionals in Ethiopia and sub-Saharan Africa working with children in early consideration and the diagnosis of the disease.

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