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Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits (constipation, diarrhea, or both), and it is often accompanied by symptoms of abdominal bloating and distension. IBS is an important he...

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Autores principales: Mamieva, Zarina, Poluektova, Elena, Svistushkin, Valery, Sobolev, Vasily, Shifrin, Oleg, Guarner, Francisco, Ivashkin, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968486/
https://www.ncbi.nlm.nih.gov/pubmed/35431513
http://dx.doi.org/10.3748/wjg.v28.i12.1204
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author Mamieva, Zarina
Poluektova, Elena
Svistushkin, Valery
Sobolev, Vasily
Shifrin, Oleg
Guarner, Francisco
Ivashkin, Vladimir
author_facet Mamieva, Zarina
Poluektova, Elena
Svistushkin, Valery
Sobolev, Vasily
Shifrin, Oleg
Guarner, Francisco
Ivashkin, Vladimir
author_sort Mamieva, Zarina
collection PubMed
description Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits (constipation, diarrhea, or both), and it is often accompanied by symptoms of abdominal bloating and distension. IBS is an important health care issue because it negatively affects the quality of life of patients and places a considerable financial burden on health care systems. Despite extensive research, the etiology and underlying pathophysiology of IBS remain incompletely understood. Proposed mechanisms involved in its pathogenesis include increased intestinal permeability, changes in the immune system, visceral hypersensitivity, impaired gut motility, and emotional disorders. Recently, accumulating evidence has highlighted the important role of the gut microbiota in the development of IBS. Microbial dysbiosis within the gut is thought to contribute to all aspects of its multifactorial pathogenesis. The last few decades have also seen an increasing interest in the impact of antibiotics on the gut microbiota. Moreover, antibiotics have been suggested to play a role in the development of IBS. Extensive research has established that antibacterial therapy induces remarkable shifts in the bacterial community composition that are quite similar to those observed in IBS. This suggestion is further supported by data from cohort and case-control studies, indicating that antibiotic treatment is associated with an increased risk of IBS. This paper summarizes the main findings on this issue and contributes to a deeper understanding of the link between antibiotic use and the development of IBS.
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spelling pubmed-89684862022-04-14 Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations? Mamieva, Zarina Poluektova, Elena Svistushkin, Valery Sobolev, Vasily Shifrin, Oleg Guarner, Francisco Ivashkin, Vladimir World J Gastroenterol Review Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits (constipation, diarrhea, or both), and it is often accompanied by symptoms of abdominal bloating and distension. IBS is an important health care issue because it negatively affects the quality of life of patients and places a considerable financial burden on health care systems. Despite extensive research, the etiology and underlying pathophysiology of IBS remain incompletely understood. Proposed mechanisms involved in its pathogenesis include increased intestinal permeability, changes in the immune system, visceral hypersensitivity, impaired gut motility, and emotional disorders. Recently, accumulating evidence has highlighted the important role of the gut microbiota in the development of IBS. Microbial dysbiosis within the gut is thought to contribute to all aspects of its multifactorial pathogenesis. The last few decades have also seen an increasing interest in the impact of antibiotics on the gut microbiota. Moreover, antibiotics have been suggested to play a role in the development of IBS. Extensive research has established that antibacterial therapy induces remarkable shifts in the bacterial community composition that are quite similar to those observed in IBS. This suggestion is further supported by data from cohort and case-control studies, indicating that antibiotic treatment is associated with an increased risk of IBS. This paper summarizes the main findings on this issue and contributes to a deeper understanding of the link between antibiotic use and the development of IBS. Baishideng Publishing Group Inc 2022-03-28 2022-03-28 /pmc/articles/PMC8968486/ /pubmed/35431513 http://dx.doi.org/10.3748/wjg.v28.i12.1204 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Mamieva, Zarina
Poluektova, Elena
Svistushkin, Valery
Sobolev, Vasily
Shifrin, Oleg
Guarner, Francisco
Ivashkin, Vladimir
Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
title Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
title_full Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
title_fullStr Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
title_full_unstemmed Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
title_short Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?
title_sort antibiotics, gut microbiota, and irritable bowel syndrome: what are the relations?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968486/
https://www.ncbi.nlm.nih.gov/pubmed/35431513
http://dx.doi.org/10.3748/wjg.v28.i12.1204
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