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Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach
Observational studies based on electronic health records (EHR) report an increased risk of neurological/neuropsychiatric sequelae for patients who have had coronavirus disease 2019 (COVID-19). However, these studies may suffer from biases such as unmeasured confounding, residual reverse causality, o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968503/ https://www.ncbi.nlm.nih.gov/pubmed/35433322 http://dx.doi.org/10.5498/wjp.v12.i3.536 |
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author | Tirozzi, Alfonsina Santonastaso, Federica de Gaetano, Giovanni Iacoviello, Licia Gialluisi, Alessandro |
author_facet | Tirozzi, Alfonsina Santonastaso, Federica de Gaetano, Giovanni Iacoviello, Licia Gialluisi, Alessandro |
author_sort | Tirozzi, Alfonsina |
collection | PubMed |
description | Observational studies based on electronic health records (EHR) report an increased risk of neurological/neuropsychiatric sequelae for patients who have had coronavirus disease 2019 (COVID-19). However, these studies may suffer from biases such as unmeasured confounding, residual reverse causality, or lack of precision in EHR-based diagnoses. To rule out these biases, we tested causal links between COVID-19 and different potential neurological/neuropsychiatric sequelae through a two-sample Mendelian randomization analysis of summary statistics from large Genome-Wide Association Scans of susceptibility to COVID-19 and different neurological and neuropsychiatric disorders, including major depression, anxiety, schizophrenia, stroke, Parkinson’s and Alzheimer’s diseases. We found robust evidence suggesting that COVID-19 – notably the hospitalized and most severe forms – carries an increased risk of neuropsychiatric sequelae, particularly Alzheimer’s disease, and to a lesser extent anxiety disorder. In line with a large longitudinal EHR-based study, this evidence was stronger for more severe COVID-19 forms. These results call for a targeted screening strategy to tackle the post-COVID neuropsychiatric pandemic. |
format | Online Article Text |
id | pubmed-8968503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-89685032022-04-14 Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach Tirozzi, Alfonsina Santonastaso, Federica de Gaetano, Giovanni Iacoviello, Licia Gialluisi, Alessandro World J Psychiatry Letter to the Editor Observational studies based on electronic health records (EHR) report an increased risk of neurological/neuropsychiatric sequelae for patients who have had coronavirus disease 2019 (COVID-19). However, these studies may suffer from biases such as unmeasured confounding, residual reverse causality, or lack of precision in EHR-based diagnoses. To rule out these biases, we tested causal links between COVID-19 and different potential neurological/neuropsychiatric sequelae through a two-sample Mendelian randomization analysis of summary statistics from large Genome-Wide Association Scans of susceptibility to COVID-19 and different neurological and neuropsychiatric disorders, including major depression, anxiety, schizophrenia, stroke, Parkinson’s and Alzheimer’s diseases. We found robust evidence suggesting that COVID-19 – notably the hospitalized and most severe forms – carries an increased risk of neuropsychiatric sequelae, particularly Alzheimer’s disease, and to a lesser extent anxiety disorder. In line with a large longitudinal EHR-based study, this evidence was stronger for more severe COVID-19 forms. These results call for a targeted screening strategy to tackle the post-COVID neuropsychiatric pandemic. Baishideng Publishing Group Inc 2022-03-19 /pmc/articles/PMC8968503/ /pubmed/35433322 http://dx.doi.org/10.5498/wjp.v12.i3.536 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Letter to the Editor Tirozzi, Alfonsina Santonastaso, Federica de Gaetano, Giovanni Iacoviello, Licia Gialluisi, Alessandro Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach |
title | Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach |
title_full | Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach |
title_fullStr | Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach |
title_full_unstemmed | Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach |
title_short | Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach |
title_sort | does covid-19 increase the risk of neuropsychiatric sequelae? evidence from a mendelian randomization approach |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968503/ https://www.ncbi.nlm.nih.gov/pubmed/35433322 http://dx.doi.org/10.5498/wjp.v12.i3.536 |
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