Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity

Despite the enormous successes of anti-PD-1/PD-L1 immunotherapy in multiple other cancer types, the overall response rates of breast cancer remain suboptimal. Therefore, exploring additional immune checkpoint molecules for potential cancer treatment is crucial. B7H3, a T-cell coinhibitory molecule,...

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Detalles Bibliográficos
Autores principales: Li, Qian, Zhong, Xiaofang, Yao, Weicheng, Yu, Junli, Wang, Chao, Li, Zongyan, Lai, Shengqing, Qu, Fanli, Fu, Xiaoyan, Huang, Xiaojia, Zhang, Dawei, Liu, Yujie, Li, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968643/
https://www.ncbi.nlm.nih.gov/pubmed/35189139
http://dx.doi.org/10.1016/j.jbc.2022.101753

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