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Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain

This work reports substrate-selective inhibition of a protease with broad substrate specificity based on direct binding of a small-molecule inhibitor to the substrate. The target for these studies was γ-secretase protease, which cleaves dozens of different single-span membrane protein substrates, in...

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Detalles Bibliográficos
Autores principales:	Castro, Manuel A., Parson, Kristine F., Beg, Ilyas, Wilkinson, Mason C., Nurmakova, Kamila, Levesque, Iliana, Voehler, Markus W., Wolfe, Michael S., Ruotolo, Brandon T., Sanders, Charles R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968665/ https://www.ncbi.nlm.nih.gov/pubmed/35247387 http://dx.doi.org/10.1016/j.jbc.2022.101792

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