Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB

Non-ribosomal peptide synthetases (NRPS) are multi-modular/domain enzymes that catalyze the synthesis of bioactive peptides. A crucial step in the process is peptide elongation accomplished by the condensation (C) domain with the aid of a peptidyl carrier or thiolation (T) domain. Here, we examined...

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Detalles Bibliográficos
Autores principales: Chu Yuan Kee, Melissa-Jane, Bharath, Sakshibeedu R., Wee, Sheena, Bowler, Matthew W., Gunaratne, Jayantha, Pan, Shenquan, Zhang, Lianhui, Song, Haiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968710/
https://www.ncbi.nlm.nih.gov/pubmed/35354859
http://dx.doi.org/10.1038/s41598-022-09188-8

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