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Efficacy and antitumor activity of a mutant type of interleukin 2

Interleukin-2 (IL-2) is an important cytokine in survival, expansion, function of CD8+ T cells and natural killer cells in immunotherapy of melanoma and renal cell carcinomas. Its severe toxicity following binding to its high affinity IL-2 receptor alpha (IL-2Rα) has restricted its application in ca...

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Detalles Bibliográficos
Autores principales:	Dehghan, Rada, Beig Parikhani, Arezoo, Zeinali, Sirous, Shokrgozar, Mohamadali, Amanzadeh, Amir, Ajdary, Soheila, Ahangari Cohan, Reza, Talebkhan, Yeganeh, Behdani, Mahdi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968711/ https://www.ncbi.nlm.nih.gov/pubmed/35354847 http://dx.doi.org/10.1038/s41598-022-09278-7

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