Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection

Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells via Ndst1f/f CD11cCre + mutation, which inhibits HS sulfatio...

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Detalles Bibliográficos
Autores principales: Kim, So Young, Gupta, Purva, Johns, Scott C., Zuniga, Elina I., Teijaro, John R., Fuster, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968721/
https://www.ncbi.nlm.nih.gov/pubmed/35354833
http://dx.doi.org/10.1038/s41598-022-09197-7

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