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Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study

BACKGROUND: Pulmonary embolism (PE) is a fatal clinical syndrome that is generally caused by an embolus from unstable deep venous thrombosis (DVT). However, clinical and biochemical factors that are related to the stability of DVT are not fully understood. AIM: To evaluate the relationships between...

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Autores principales: Meng, Yan, Li, You, Ye, Yan-Jun, Ma, Qiang, Zhang, Jun-Bo, Qin, Hao, Deng, Yang-Yang, Tian, Hong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968801/
https://www.ncbi.nlm.nih.gov/pubmed/35434115
http://dx.doi.org/10.12998/wjcc.v10.i9.2700
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author Meng, Yan
Li, You
Ye, Yan-Jun
Ma, Qiang
Zhang, Jun-Bo
Qin, Hao
Deng, Yang-Yang
Tian, Hong-Yan
author_facet Meng, Yan
Li, You
Ye, Yan-Jun
Ma, Qiang
Zhang, Jun-Bo
Qin, Hao
Deng, Yang-Yang
Tian, Hong-Yan
author_sort Meng, Yan
collection PubMed
description BACKGROUND: Pulmonary embolism (PE) is a fatal clinical syndrome that is generally caused by an embolus from unstable deep venous thrombosis (DVT). However, clinical and biochemical factors that are related to the stability of DVT are not fully understood. AIM: To evaluate the relationships between plasma antigen levels of factor XII (FXII:Ag) and factor XI (FXI:Ag) with the stability of DVT. METHODS: Patients with DVT and no PE, DVT and PE, and controls with no DVT or PE that matched for age, gender, and comorbidities were included in this study. FXII:Ag and FXI:Ag in peripheral venous blood were measured using enzyme-linked immunosorbent assays. RESULTS: Using the 95(th) percentile of FXI:Ag in patients with DVT and PE as the cut-off, a higher FXI:Ag was associated with a higher risk of unstable DVT (odds ratio: 3.15, 95% confidence interval: 1.18-8.43, P = 0.019). Stratified analyses showed consistent results in patients ≤ 60 years (P = 0.020), but not in those > 60 years (P = 0.346). CONCLUSION: Higher plasma FXI:Ag might be a marker for unstable DVT, which might be associated with PE in these patients.
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spelling pubmed-89688012022-04-14 Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study Meng, Yan Li, You Ye, Yan-Jun Ma, Qiang Zhang, Jun-Bo Qin, Hao Deng, Yang-Yang Tian, Hong-Yan World J Clin Cases Case Control Study BACKGROUND: Pulmonary embolism (PE) is a fatal clinical syndrome that is generally caused by an embolus from unstable deep venous thrombosis (DVT). However, clinical and biochemical factors that are related to the stability of DVT are not fully understood. AIM: To evaluate the relationships between plasma antigen levels of factor XII (FXII:Ag) and factor XI (FXI:Ag) with the stability of DVT. METHODS: Patients with DVT and no PE, DVT and PE, and controls with no DVT or PE that matched for age, gender, and comorbidities were included in this study. FXII:Ag and FXI:Ag in peripheral venous blood were measured using enzyme-linked immunosorbent assays. RESULTS: Using the 95(th) percentile of FXI:Ag in patients with DVT and PE as the cut-off, a higher FXI:Ag was associated with a higher risk of unstable DVT (odds ratio: 3.15, 95% confidence interval: 1.18-8.43, P = 0.019). Stratified analyses showed consistent results in patients ≤ 60 years (P = 0.020), but not in those > 60 years (P = 0.346). CONCLUSION: Higher plasma FXI:Ag might be a marker for unstable DVT, which might be associated with PE in these patients. Baishideng Publishing Group Inc 2022-03-26 2022-03-26 /pmc/articles/PMC8968801/ /pubmed/35434115 http://dx.doi.org/10.12998/wjcc.v10.i9.2700 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Control Study
Meng, Yan
Li, You
Ye, Yan-Jun
Ma, Qiang
Zhang, Jun-Bo
Qin, Hao
Deng, Yang-Yang
Tian, Hong-Yan
Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
title Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
title_full Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
title_fullStr Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
title_full_unstemmed Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
title_short Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
title_sort associations between coagulation factor xii, coagulation factor xi, and stability of venous thromboembolism: a case-control study
topic Case Control Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968801/
https://www.ncbi.nlm.nih.gov/pubmed/35434115
http://dx.doi.org/10.12998/wjcc.v10.i9.2700
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