Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome

Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clona...

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Detalles Bibliográficos
Autores principales: Tovy, Ayala, Rosas, Carina, Gaikwad, Amos S., Medrano, Geraldo, Zhang, Linda, Reyes, Jaime M., Huang, Yung-Hsin, Arakawa, Tatsuhiko, Kurtz, Kristen, Conneely, Shannon E., Guzman, Anna G., Aguilar, Rogelio, Gao, Anne, Chen, Chun-Wei, Kim, Jean J., Carter, Melissa T., Lasa-Aranzasti, Amaia, Valenzuela, Irene, Maldergem, Lionel Van, Brunetti, Lorenzo, Hicks, M. John, Marcogliese, Andrea N., Goodell, Margaret A., Rau, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968878/
https://www.ncbi.nlm.nih.gov/pubmed/34092059
http://dx.doi.org/10.3324/haematol.2021.278990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968878/
https://www.ncbi.nlm.nih.gov/pubmed/34092059
http://dx.doi.org/10.3324/haematol.2021.278990

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