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Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia

Dysregulation of apoptotic machinery is one mechanism by which acute myeloid leukemia (AML) acquires a clonal survival advantage. B-cell lymphoma protein-2 (BCL2) overexpression is a common feature in hematologic malignancies. The selective BCL2 inhibitor, venetoclax (VEN) is used in combination wit...

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Detalles Bibliográficos
Autores principales:	Cojocari, Dan, Smith, Brianna N, Purkal, Julie J., Arrate, Maria P., Huska, Jason D., Xiao, Yu, Gorska, Agnieszka, Hogdal, Leah J., Ramsey, Haley E., Boghaert, Erwin R., Phillips, Darren C., Savona, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968901/ https://www.ncbi.nlm.nih.gov/pubmed/33853293 http://dx.doi.org/10.3324/haematol.2020.272609

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