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The GPIbα intracellular tail - role in transducing VWF- and collagen/GPVI-mediated signaling

The GPIbα-VWF A1 domain interaction is essential for platelet tethering under high shear. Synergy between GPIbα and GPVI signaling machineries has been suggested previously, however its molecular mechanism remains unclear. We generated a novel GPIbα transgenic mouse (GpIba(Δsig/Δsig)) by CRISPR-Cas9...

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Detalles Bibliográficos
Autores principales:	Constantinescu-Bercu, Adela, Wang, Yuxiao A, Woollard, Kevin J, Mangin, Pierre, Vanhoorelbeke, Karen, Crawley, James TB, Salles-Crawley, Isabelle I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968903/ https://www.ncbi.nlm.nih.gov/pubmed/34134470 http://dx.doi.org/10.3324/haematol.2020.278242

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