IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load

Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and developed a procedure to stratify patients based on me...

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Detalles Bibliográficos
Autores principales: Hussmann, Dianna, Starnawska, Anna, Kristensen, Louise, Daugaard, Iben, Thomsen, Astrid, Kjeldsen, Tina E., Hansen, Christine Søholm, Bybjerg-Grauholm, Jonas, Johansen, Karina Dalsgaard, Ludvigsen, Maja, Kristensen, Thomas, Larsen, Thomas Stauffer, Møller, Michael Boe, Nyvold, Charlotte Guldborg, Hansen, Lise Lotte, Wojdacz, Tomasz K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968906/
https://www.ncbi.nlm.nih.gov/pubmed/34092057
http://dx.doi.org/10.3324/haematol.2021.278477

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