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Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains

Inhibition of DNA repair enzymes is an attractive target for increasing the efficacy of DNA damaging chemotherapies. The ERCC1-XPF heterodimer is a key endonuclease in numerous single and double strand break repair processes, and inhibition of the heterodimerization has previously been shown to sens...

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Detalles Bibliográficos
Autores principales:	Weilbeer, Claudia, Jay, David, Donnelly, James C., Gentile, Francesco, Karimi-Busheri, Feridoun, Yang, Xiaoyan, Mani, Rajam S., Yu, Yaping, Elmenoufy, Ahmed H., Barakat, Khaled H., Tuszynski, Jack A., Weinfeld, Michael, West, Frederick G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968952/ https://www.ncbi.nlm.nih.gov/pubmed/35372043 http://dx.doi.org/10.3389/fonc.2022.819172

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