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Decomposition of Disparities in Alzheimer’s Disease and Related Dementia
This study uses Medicare data to non-parametrically evaluate race- and place-of-residence-related disparities in AD/ADRD prevalence and incidence-based mortality, separate them out into the epidemiological causal components including race-related disparities in incidence and survival, and finally ex...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969027/ http://dx.doi.org/10.1093/geroni/igab046.1063 |
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author | Akushevich, Igor |
author_facet | Akushevich, Igor |
author_sort | Akushevich, Igor |
collection | PubMed |
description | This study uses Medicare data to non-parametrically evaluate race- and place-of-residence-related disparities in AD/ADRD prevalence and incidence-based mortality, separate them out into the epidemiological causal components including race-related disparities in incidence and survival, and finally explain these in terms of health-care-related factors using causal methods of group variable effects (propensity scores and the rank-and-replace method) and regression-based analyses (extended Fairlie’s model and generalized Oaxaca-Blinder approach for censoring outcomes). Partitioning analysis showed that the incidence rate is the main predictor for temporal changes and racial disparities in AD/ADRD prevalence and mortality, though survival began to play a role after 2010. Arterial hypertension is the leading predictor responsible for racial disparities in AD/ADRD risks. This study demonstrated that Medicare data has sufficient statistical power and potential for studying disparities in AD/ADRD in three interacting directions: multi-ethnic structure of population, place of residence, and time period. |
format | Online Article Text |
id | pubmed-8969027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89690272022-04-01 Decomposition of Disparities in Alzheimer’s Disease and Related Dementia Akushevich, Igor Innov Aging Abstracts This study uses Medicare data to non-parametrically evaluate race- and place-of-residence-related disparities in AD/ADRD prevalence and incidence-based mortality, separate them out into the epidemiological causal components including race-related disparities in incidence and survival, and finally explain these in terms of health-care-related factors using causal methods of group variable effects (propensity scores and the rank-and-replace method) and regression-based analyses (extended Fairlie’s model and generalized Oaxaca-Blinder approach for censoring outcomes). Partitioning analysis showed that the incidence rate is the main predictor for temporal changes and racial disparities in AD/ADRD prevalence and mortality, though survival began to play a role after 2010. Arterial hypertension is the leading predictor responsible for racial disparities in AD/ADRD risks. This study demonstrated that Medicare data has sufficient statistical power and potential for studying disparities in AD/ADRD in three interacting directions: multi-ethnic structure of population, place of residence, and time period. Oxford University Press 2021-12-17 /pmc/articles/PMC8969027/ http://dx.doi.org/10.1093/geroni/igab046.1063 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Akushevich, Igor Decomposition of Disparities in Alzheimer’s Disease and Related Dementia |
title | Decomposition of Disparities in Alzheimer’s Disease and Related Dementia |
title_full | Decomposition of Disparities in Alzheimer’s Disease and Related Dementia |
title_fullStr | Decomposition of Disparities in Alzheimer’s Disease and Related Dementia |
title_full_unstemmed | Decomposition of Disparities in Alzheimer’s Disease and Related Dementia |
title_short | Decomposition of Disparities in Alzheimer’s Disease and Related Dementia |
title_sort | decomposition of disparities in alzheimer’s disease and related dementia |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969027/ http://dx.doi.org/10.1093/geroni/igab046.1063 |
work_keys_str_mv | AT akushevichigor decompositionofdisparitiesinalzheimersdiseaseandrelateddementia |