Cargando…

Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis

BACKGROUND: Both transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are effective methods for the treatment of recurrent hepatocellular carcinoma (RHCC). Thus far, it is unclear which method is more satisfactory in short- and long-term survival benefits. PURPOSE: To compare the...

Descripción completa

Detalles Bibliográficos
Autores principales: Gou, Haoxian, Liu, Shenglu, Zhu, Gang, Peng, Yisheng, Li, Xinkai, Yang, Xiaoli, He, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969051/
https://www.ncbi.nlm.nih.gov/pubmed/35368406
http://dx.doi.org/10.1177/20584601221085514
_version_ 1784679178161881088
author Gou, Haoxian
Liu, Shenglu
Zhu, Gang
Peng, Yisheng
Li, Xinkai
Yang, Xiaoli
He, Kai
author_facet Gou, Haoxian
Liu, Shenglu
Zhu, Gang
Peng, Yisheng
Li, Xinkai
Yang, Xiaoli
He, Kai
author_sort Gou, Haoxian
collection PubMed
description BACKGROUND: Both transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are effective methods for the treatment of recurrent hepatocellular carcinoma (RHCC). Thus far, it is unclear which method is more satisfactory in short- and long-term survival benefits. PURPOSE: To compare the overall survival (OS) and complications of TACE and RFA used for the management of RHCC. MATERIAL AND METHODS: A literature search was carried out using PubMed, the Cochrane Library and, Embase databases, and Google Scholar, keywords including “RHCC,” “TACEC,” and “RFA” with a cutoff date of 30 April 2021. Used Review Manager software was to calculate short- and long-term OS. The clinical outcomes are major complications and complete response (CR). RESULTS: Finally, nine clinical trials met the research standard, including 1326 subjects, of which 518 received RFA and 808 received TACE. The analysis showed that patients who underwent RFA had significantly higher 1-, 3-, and 5-year OS (OR(1-year) = 1.92, 95% confidence interval (CI) = 1.27–2.91, p = .002; OR(3-year) = 1.64, 95% CI = 1.30–2.08, p <.0001; OR(5-year) = 3.22, 95% CI = 1.34–7.72, p=.009). Besides, the patients who chose RFA had an obvious higher rate of CR than those receiving TACE (OR = 33.75, 95% CI = 1.73–658.24, p = .002). However, the major complications were consistency between these two groups. CONCLUSION: Our study discovered that RFA had greater CR and incidence in both the short-term and long-term OS than TACE. In addition, obvious difference was not found in major complications in these two methods.
format Online
Article
Text
id pubmed-8969051
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-89690512022-04-01 Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis Gou, Haoxian Liu, Shenglu Zhu, Gang Peng, Yisheng Li, Xinkai Yang, Xiaoli He, Kai Acta Radiol Open Review BACKGROUND: Both transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are effective methods for the treatment of recurrent hepatocellular carcinoma (RHCC). Thus far, it is unclear which method is more satisfactory in short- and long-term survival benefits. PURPOSE: To compare the overall survival (OS) and complications of TACE and RFA used for the management of RHCC. MATERIAL AND METHODS: A literature search was carried out using PubMed, the Cochrane Library and, Embase databases, and Google Scholar, keywords including “RHCC,” “TACEC,” and “RFA” with a cutoff date of 30 April 2021. Used Review Manager software was to calculate short- and long-term OS. The clinical outcomes are major complications and complete response (CR). RESULTS: Finally, nine clinical trials met the research standard, including 1326 subjects, of which 518 received RFA and 808 received TACE. The analysis showed that patients who underwent RFA had significantly higher 1-, 3-, and 5-year OS (OR(1-year) = 1.92, 95% confidence interval (CI) = 1.27–2.91, p = .002; OR(3-year) = 1.64, 95% CI = 1.30–2.08, p <.0001; OR(5-year) = 3.22, 95% CI = 1.34–7.72, p=.009). Besides, the patients who chose RFA had an obvious higher rate of CR than those receiving TACE (OR = 33.75, 95% CI = 1.73–658.24, p = .002). However, the major complications were consistency between these two groups. CONCLUSION: Our study discovered that RFA had greater CR and incidence in both the short-term and long-term OS than TACE. In addition, obvious difference was not found in major complications in these two methods. SAGE Publications 2022-03-29 /pmc/articles/PMC8969051/ /pubmed/35368406 http://dx.doi.org/10.1177/20584601221085514 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Gou, Haoxian
Liu, Shenglu
Zhu, Gang
Peng, Yisheng
Li, Xinkai
Yang, Xiaoli
He, Kai
Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis
title Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis
title_full Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis
title_fullStr Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis
title_full_unstemmed Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis
title_short Effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: A meta-analysis
title_sort effectiveness of radiofrequency ablation versus transarterial chemoembolization for recurrent hepatocellular carcinoma: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969051/
https://www.ncbi.nlm.nih.gov/pubmed/35368406
http://dx.doi.org/10.1177/20584601221085514
work_keys_str_mv AT gouhaoxian effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis
AT liushenglu effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis
AT zhugang effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis
AT pengyisheng effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis
AT lixinkai effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis
AT yangxiaoli effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis
AT hekai effectivenessofradiofrequencyablationversustransarterialchemoembolizationforrecurrenthepatocellularcarcinomaametaanalysis