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Steroidal Antagonists of Progesterone- and Prostaglandin E(1)-Induced Activation of the Cation Channel of Sperm

The cation channel of sperm (CatSper) is the principal entry point for calcium in human spermatozoa and its proper function is essential for successful fertilization. As CatSper is potently activated by progesterone, we evaluated a range of steroids to define the structure-activity relationships for...

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Detalles Bibliográficos
Autores principales:	Carlson, Erick J., Georg, Gunda I., Hawkinson, Jon E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969127/ https://www.ncbi.nlm.nih.gov/pubmed/34718225 http://dx.doi.org/10.1124/molpharm.121.000349

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