Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be nonenzymatically driven by glutaryl-CoA. In mamm...

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Detalles Bibliográficos
Autores principales: Bhatt, Dhaval P., Mills, C. Allie, Anderson, Kristin A., Henriques, Bárbara J., Lucas, Tânia G., Francisco, Sara, Liu, Juan, Ilkayeva, Olga R., Adams, Alexander E., Kulkarni, Shreyas R., Backos, Donald S., Major, Michael B., Grimsrud, Paul A., Gomes, Cláudio M., Hirschey, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969154/
https://www.ncbi.nlm.nih.gov/pubmed/35157847
http://dx.doi.org/10.1016/j.jbc.2022.101723

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