Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis

Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjace...

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Detalles Bibliográficos
Autores principales: Zha, Quanbin, Wu, Xi, Zhang, Jingxin, Xu, Tingting, Shi, YongKang, Sun, Yayun, Fang, Yuan, Gu, Yunru, Ma, Pei, Shu, Yongqian, Tian, Shengwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969178/
https://www.ncbi.nlm.nih.gov/pubmed/35354791
http://dx.doi.org/10.1038/s41420-022-00954-1
Descripción
Sumario:Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.

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