Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis

Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjace...

Descripción completa

Detalles Bibliográficos
Autores principales: Zha, Quanbin, Wu, Xi, Zhang, Jingxin, Xu, Tingting, Shi, YongKang, Sun, Yayun, Fang, Yuan, Gu, Yunru, Ma, Pei, Shu, Yongqian, Tian, Shengwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969178/
https://www.ncbi.nlm.nih.gov/pubmed/35354791
http://dx.doi.org/10.1038/s41420-022-00954-1
_version_ 1784679197864624128
author Zha, Quanbin
Wu, Xi
Zhang, Jingxin
Xu, Tingting
Shi, YongKang
Sun, Yayun
Fang, Yuan
Gu, Yunru
Ma, Pei
Shu, Yongqian
Tian, Shengwang
author_facet Zha, Quanbin
Wu, Xi
Zhang, Jingxin
Xu, Tingting
Shi, YongKang
Sun, Yayun
Fang, Yuan
Gu, Yunru
Ma, Pei
Shu, Yongqian
Tian, Shengwang
author_sort Zha, Quanbin
collection PubMed
description Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.
format Online
Article
Text
id pubmed-8969178
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-89691782022-04-20 Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis Zha, Quanbin Wu, Xi Zhang, Jingxin Xu, Tingting Shi, YongKang Sun, Yayun Fang, Yuan Gu, Yunru Ma, Pei Shu, Yongqian Tian, Shengwang Cell Death Discov Article Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment. Nature Publishing Group UK 2022-03-30 /pmc/articles/PMC8969178/ /pubmed/35354791 http://dx.doi.org/10.1038/s41420-022-00954-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zha, Quanbin
Wu, Xi
Zhang, Jingxin
Xu, Tingting
Shi, YongKang
Sun, Yayun
Fang, Yuan
Gu, Yunru
Ma, Pei
Shu, Yongqian
Tian, Shengwang
Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
title Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
title_full Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
title_fullStr Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
title_full_unstemmed Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
title_short Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
title_sort hsa_circ_0007967 promotes gastric cancer proliferation through the mir-411-5p/maml3 axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969178/
https://www.ncbi.nlm.nih.gov/pubmed/35354791
http://dx.doi.org/10.1038/s41420-022-00954-1
work_keys_str_mv AT zhaquanbin hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT wuxi hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT zhangjingxin hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT xutingting hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT shiyongkang hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT sunyayun hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT fangyuan hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT guyunru hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT mapei hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT shuyongqian hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis
AT tianshengwang hsacirc0007967promotesgastriccancerproliferationthroughthemir4115pmaml3axis

Ejemplares similares