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Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation
BACKGROUND: With the growing practice of home mechanical ventilation, there is a need to identify biological markers for adequate follow-up. Red cell distribution width (RDW) is a promising candidate because it is convenient, objective and may reflect treatment effect over a long period of time. The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969261/ https://www.ncbi.nlm.nih.gov/pubmed/35354396 http://dx.doi.org/10.1186/s12890-022-01916-0 |
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author | Valko, Luca Baglyas, Szabolcs Podmaniczky, Eszter Prohaszka, Zoltan Gal, Janos Lorx, Andras |
author_facet | Valko, Luca Baglyas, Szabolcs Podmaniczky, Eszter Prohaszka, Zoltan Gal, Janos Lorx, Andras |
author_sort | Valko, Luca |
collection | PubMed |
description | BACKGROUND: With the growing practice of home mechanical ventilation, there is a need to identify biological markers for adequate follow-up. Red cell distribution width (RDW) is a promising candidate because it is convenient, objective and may reflect treatment effect over a long period of time. The aim of this study was to explore the possible role of RDW as a marker for home mechanical ventilation in real-life, unselected chronic respiratory patient populations. METHODS: First, we identified characteristic RDW values for mixed case, unselected chronic respiratory failure and home mechanical ventilated patients through retrospective review within our institutional database. Next, we conducted a prospective observational study to identify RDW changes during the first six months of optimized home mechanical ventilation treatment. Adult patients starting home mechanical ventilation were included. Factors affecting RDW change during the first 6 months of treatment were analysed. RESULTS: RDW was elevated in both chronic respiratory failure and home mechanical ventilation patients compared to healthy individuals in the retrospective review. In the prospective study of 70 patients, we found that 55.4% of patients starting home mechanical ventilation have abnormal RDW values which are reduced from 14.7 (IQR = 13.2–16.2)% to 13.5 (IQR = 13.1–14.6)% during the first 6 months of HMV treatment (p < 0.001). RDW improvement correlates with improvement in self-reported health-related quality of life and sleepiness scale scores, as well as physical functional status during the same time frame. RDW proved to be a comparable marker to other parameters traditionally used to evaluate treatment efficacy. CONCLUSIONS: RDW is elevated in chronic respiratory failure patients and is significantly reduced in the first six months of optimized home mechanical ventilation. Although further research is needed to verify if RDW change reflects outcome and how comorbidities influence RDW values, our results suggest that RDW is a promising marker of home mechanical ventilation efficacy. Trial registration This study was approved by and registered at the ethics committee of Semmelweis University (TUKEB 250/2017 and TUKEB 250-1/2017, 20th of December 2017 and 1st of October 2019). |
format | Online Article Text |
id | pubmed-8969261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89692612022-04-01 Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation Valko, Luca Baglyas, Szabolcs Podmaniczky, Eszter Prohaszka, Zoltan Gal, Janos Lorx, Andras BMC Pulm Med Research BACKGROUND: With the growing practice of home mechanical ventilation, there is a need to identify biological markers for adequate follow-up. Red cell distribution width (RDW) is a promising candidate because it is convenient, objective and may reflect treatment effect over a long period of time. The aim of this study was to explore the possible role of RDW as a marker for home mechanical ventilation in real-life, unselected chronic respiratory patient populations. METHODS: First, we identified characteristic RDW values for mixed case, unselected chronic respiratory failure and home mechanical ventilated patients through retrospective review within our institutional database. Next, we conducted a prospective observational study to identify RDW changes during the first six months of optimized home mechanical ventilation treatment. Adult patients starting home mechanical ventilation were included. Factors affecting RDW change during the first 6 months of treatment were analysed. RESULTS: RDW was elevated in both chronic respiratory failure and home mechanical ventilation patients compared to healthy individuals in the retrospective review. In the prospective study of 70 patients, we found that 55.4% of patients starting home mechanical ventilation have abnormal RDW values which are reduced from 14.7 (IQR = 13.2–16.2)% to 13.5 (IQR = 13.1–14.6)% during the first 6 months of HMV treatment (p < 0.001). RDW improvement correlates with improvement in self-reported health-related quality of life and sleepiness scale scores, as well as physical functional status during the same time frame. RDW proved to be a comparable marker to other parameters traditionally used to evaluate treatment efficacy. CONCLUSIONS: RDW is elevated in chronic respiratory failure patients and is significantly reduced in the first six months of optimized home mechanical ventilation. Although further research is needed to verify if RDW change reflects outcome and how comorbidities influence RDW values, our results suggest that RDW is a promising marker of home mechanical ventilation efficacy. Trial registration This study was approved by and registered at the ethics committee of Semmelweis University (TUKEB 250/2017 and TUKEB 250-1/2017, 20th of December 2017 and 1st of October 2019). BioMed Central 2022-03-30 /pmc/articles/PMC8969261/ /pubmed/35354396 http://dx.doi.org/10.1186/s12890-022-01916-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Valko, Luca Baglyas, Szabolcs Podmaniczky, Eszter Prohaszka, Zoltan Gal, Janos Lorx, Andras Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
title | Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
title_full | Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
title_fullStr | Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
title_full_unstemmed | Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
title_short | Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
title_sort | exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969261/ https://www.ncbi.nlm.nih.gov/pubmed/35354396 http://dx.doi.org/10.1186/s12890-022-01916-0 |
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