Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models

BACKGROUND AND OBJECTIVES: Siponimod is an oral, selective sphingosine-1-phosphate receptor-1/5 modulator approved for treatment of multiple sclerosis. METHODS: Mouse MRI was used to investigate remyelination in the cuprizone model. We then used a conditional demyelination Xenopus laevis model to as...

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Detalles Bibliográficos
Autores principales: Dietrich, Michael, Hecker, Christina, Martin, Elodie, Langui, Dominique, Gliem, Michael, Stankoff, Bruno, Lubetzki, Catherine, Gruchot, Joel, Göttle, Peter, Issberner, Andrea, Nasiri, Milad, Ramseier, Pamela, Beerli, Christian, Tisserand, Sarah, Beckmann, Nicolau, Shimshek, Derya, Petzsch, Patrick, Akbar, David, Levkau, Bodo, Stark, Holger, Köhrer, Karl, Hartung, Hans-Peter, Küry, Patrick, Meuth, Sven Günther, Bigaud, Marc, Zalc, Bernard, Albrecht, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969301/
https://www.ncbi.nlm.nih.gov/pubmed/35354603
http://dx.doi.org/10.1212/NXI.0000000000001161

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