Progress in germline stem cell transplantation in mammals and the potential usage

Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation. Therefore, GSCs transplantation is a promising technique for fertility...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Wen, Nie, Ruotian, Cai, Yihui, Xie, Wenhai, Zou, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969385/
https://www.ncbi.nlm.nih.gov/pubmed/35361229
http://dx.doi.org/10.1186/s12958-022-00930-5
_version_ 1784679234968485888
author Zhang, Wen
Nie, Ruotian
Cai, Yihui
Xie, Wenhai
Zou, Kang
author_facet Zhang, Wen
Nie, Ruotian
Cai, Yihui
Xie, Wenhai
Zou, Kang
author_sort Zhang, Wen
collection PubMed
description Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation. Therefore, GSCs transplantation is a promising technique for fertility recovery in the clinic, protection of rare animals and livestock breeding. Though this novel technique faces tremendous challenges, numerous achievements have been made after several decades’ endeavor. This review summarizes the current knowledge of GSCs transplantation and its utilization in mammals, and discusses the application prospect in reproductive medicine and animal science.
format Online
Article
Text
id pubmed-8969385
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-89693852022-04-01 Progress in germline stem cell transplantation in mammals and the potential usage Zhang, Wen Nie, Ruotian Cai, Yihui Xie, Wenhai Zou, Kang Reprod Biol Endocrinol Review Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation. Therefore, GSCs transplantation is a promising technique for fertility recovery in the clinic, protection of rare animals and livestock breeding. Though this novel technique faces tremendous challenges, numerous achievements have been made after several decades’ endeavor. This review summarizes the current knowledge of GSCs transplantation and its utilization in mammals, and discusses the application prospect in reproductive medicine and animal science. BioMed Central 2022-03-31 /pmc/articles/PMC8969385/ /pubmed/35361229 http://dx.doi.org/10.1186/s12958-022-00930-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Wen
Nie, Ruotian
Cai, Yihui
Xie, Wenhai
Zou, Kang
Progress in germline stem cell transplantation in mammals and the potential usage
title Progress in germline stem cell transplantation in mammals and the potential usage
title_full Progress in germline stem cell transplantation in mammals and the potential usage
title_fullStr Progress in germline stem cell transplantation in mammals and the potential usage
title_full_unstemmed Progress in germline stem cell transplantation in mammals and the potential usage
title_short Progress in germline stem cell transplantation in mammals and the potential usage
title_sort progress in germline stem cell transplantation in mammals and the potential usage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969385/
https://www.ncbi.nlm.nih.gov/pubmed/35361229
http://dx.doi.org/10.1186/s12958-022-00930-5
work_keys_str_mv AT zhangwen progressingermlinestemcelltransplantationinmammalsandthepotentialusage
AT nieruotian progressingermlinestemcelltransplantationinmammalsandthepotentialusage
AT caiyihui progressingermlinestemcelltransplantationinmammalsandthepotentialusage
AT xiewenhai progressingermlinestemcelltransplantationinmammalsandthepotentialusage
AT zoukang progressingermlinestemcelltransplantationinmammalsandthepotentialusage

Ejemplares similares